Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men
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This study for the first time investigates the association of bone mineral density (BMD) with angiographically determined coronary atherosclerosis in men. Our data show that the prevalence of low BMD is very high in men undergoing coronary angiography. However, neither osteopenia nor osteoporosis is associated with an increased prevalence of angiographically determined coronary atherosclerosis.
The association of low BMD with angiographically determined coronary atherosclerosis in men is unknown.
We enrolled 623 consecutive men undergoing coronary angiography for the evaluation of established or suspected coronary artery disease (CAD). BMD was assessed by dual X-ray absorptiometry. CAD was diagnosed in the presence of any coronary artery lumen narrowing at angiography; coronary stenoses with lumen narrowing ≥50% were considered significant.
From the total study cohort (mean age of 64 ± 11 years), 207 patients (33.2%) had osteopenia and 65 (10.4%) had osteoporosis; at angiography, CAD was diagnosed in 558 patients (89.6%) and 403 (64.7%) had significant coronary stenoses. In multivariate logistic regression analysis neither osteopenia nor osteoporosis was associated with an increased prevalence of CAD (adjusted odds ratios (ORs) = 0.71 [95% confidence interval 0.40–1.23]; p = 0.222 and 1.03 [0.38–2.80]; p = 0.955, respectively) or with significant coronary stenoses (OR 0.74 [0.52–1.07], p = 0.112 and 0.72 [0.41–1.26]; p = 0.251, respectively). Also, as a continuous variable, BMD was not associated with angiographically diagnosed CAD.
The prevalence of low BMD is very high in men undergoing coronary angiography. However, low BMD is not associated with angiographically determined coronary atherosclerosis in men.
KeywordsAtherosclerosis Bone mineral density Cardiovascular risk Coronary angiography Dual X-ray absorptiometry
The VIVIT institute thanks Dr. Egmond Frommelt and the Innovationsstiftung of the Liechtenstein Global Trust (LGT) Bank (Bendern, Liechtenstein), Dr. Karl Josef Hier, Peter Goop Stiftung (Vaduz, Liechtenstein), Gabriela Dür and the Vorarlberger Landesregierung (Bregenz, Austria), Prof. Willi A. Ribi and the University of the Principality of Liechtenstein, as well as the Fachhochschule Dornbirn (Dornbirn, Austria) for providing us with generous research grants. We are grateful to Franz Rauch and the Vorarlberger Industriellenvereinigung (Bregenz, Austria), to Dr. Peter Woess and the Vorarlberger Aerztekammer (Dornbirn, Austria), to Dr. Elmar Bechter, and to Luis Patsch, Drs. Gerald Fleisch and Till Hornung, Directors, Vorarlberger Landeskrankenhaus-Betriebsgesellschaft (Feldkirch, Austria), for continuously supporting our Research Institute. The study was part-financed by the ‘Land Vorarlberg’ and the ‘Europaeischer Fonds fuer regionale Entwicklung’ (EFRE). The sponsor did not participate in analyses or influence the decision to submit for publication.
Conflicts of interest
- 34.Muendlein A, Saely CH, Marte T et al (2008) Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3–482 C>T polymorphisms on their association with coronary artery disease. Atherosclerosis 199:179–186CrossRefPubMedGoogle Scholar