Osteoporosis International

, Volume 21, Issue 5, pp 855–862 | Cite as

Neovascular AMD: an overlooked risk factor for injurious falls

  • S. M. SzaboEmail author
  • P. A. Janssen
  • K. Khan
  • S. R. Lord
  • M. J. Potter
Original Article



While those with neovascular age-related macular degeneration (NV-AMD) may be at increased risk of injurious falls risk due to poor central vision and suboptimal responses when falling, preserved peripheral vision and decreased activity levels may actually be protective. Compared with control participants, patients with NV-AMD had a significantly greater number of falls and almost twice the risk of injurious falls.


Impaired vision, particularly peripheral visual function, is a key risk factor for injurious falls. NV-AMD is a leading cause of severely impaired vision among older adults but is associated with a profound central, rather than peripheral, deficit. The objective was to determine whether older women with NV-AMD are at an increased risk of falls or injurious falls.


We conducted a 12-month prospective cohort study of community-dwelling older (≥70 years) women, enrolling 114 with NV-AMD and 132 without from a retinal clinic in Vancouver, Canada. Fall incidence was determined through monthly telephone follow-up, with fall severity classified by a blinded reviewer. We compared mean injurious falls per person-year between groups using negative binomial regression.


A mean of 0.37 injurious falls per person-year were experienced among NV-AMD participants, compared to 0.16 injurious falls per person-year among non-NV-AMD participants (p = 0.006). The age-adjusted incidence rate ratio for injurious falls, for an individual with NV-AMD compared to without, was 1.77 (1.07–3.02).


Older women with NV-AMD are at almost twice the risk of injurious falls compared to those without. Clinicians caring for older adults should recognise NV-AMD as an important risk factor for injurious falls.


Age-related macular degeneration (AMD) Elderly Falls Prevention 



I affirm that I have listed everyone who contributed significantly to the work and have obtained written consent from all contributors who are not authors but are listed in the “Acknowledgements” section. The authors thank the Centre for Hip Health & Mobility, Vancouver Coastal Health Research Institute, and the Michael Smith Foundation for Health Research for funding. The authors are indebted to Marian Brlecic, BA, Cheryl Claudio, MSc, and Teresa Lee, MScPT, for assistance in recruitment and assessment of participants.

Conflicts of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  • S. M. Szabo
    • 1
    • 2
    • 3
    • 5
    Email author
  • P. A. Janssen
    • 1
    • 3
  • K. Khan
    • 3
  • S. R. Lord
    • 4
  • M. J. Potter
    • 2
  1. 1.School of Population and Public Health & EpidemiologyUniversity of British ColumbiaVancouverCanada
  2. 2.Department of Ophthalmology & Visual SciencesUniversity of British ColumbiaVancouverCanada
  3. 3.Vancouver Coastal Health Research InstituteCentre for Hip Health & MobilityVancouverCanada
  4. 4.Prince of Wales Medical Research Institute, UNSWSydneyAustralia
  5. 5.Centre for Hip Health and MobilityVancouverCanada

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