Osteoporosis International

, Volume 21, Issue 5, pp 837–846 | Cite as

Preference and satisfaction with a 6-month subcutaneous injection versus a weekly tablet for treatment of low bone mass

  • D. L. Kendler
  • L. Bessette
  • C. D. Hill
  • D. T. Gold
  • R. Horne
  • S. F. Varon
  • J. Borenstein
  • H. Wang
  • H.-S. Man
  • R. B. Wagman
  • S. Siddhanti
  • D. Macarios
  • H. G. Bone
Original Article



The Preference and Satisfaction Questionnaire (PSQ) compares patient preference and satisfaction between a 6-month subcutaneous injection and weekly oral tablet for treatment of bone loss. Patients preferred and were more satisfied with a treatment that was administered less frequently, suggesting the acceptability of the 6-month injection for treatment of bone loss.


The PSQ compares patient preference and satisfaction between a 6-month subcutaneous injection and a weekly oral tablet for treatment of bone loss.


Postmenopausal women with low bone mass who enrolled in two separate randomized phase 3 double-blind, double-dummy studies received a 6-month subcutaneous denosumab injection (60 mg) plus a weekly oral placebo or a weekly alendronate tablet (70 mg) plus a 6-month subcutaneous placebo injection. After 12 months, patients completed the PSQ to rate their preference, satisfaction, and degree of bother with each regimen.


Most enrolled patients (1,583 out of 1,693; 93.5%) answered ≥1 item of the PSQ. Significantly more patients preferred and were more satisfied with the 6-month injection versus the weekly tablet (P < 0.001). More patients reported no bother with the 6-month injection (90%) than the weekly tablet (62%).


Patients preferred, were more satisfied, and less bothered with a 6-month injection regimen for osteoporosis.


Injection Osteoporosis Preference Questionnaire Satisfaction Tablet 



Funding for these studies was provided by Amgen Inc., Thousand Oaks, CA USA. Sacha Satram-Hoang, Ph.D. and Amy Foreman-Wykert, Ph.D. (Amgen, Inc.) provided editorial and writing assistance.

Conflicts of interest

The authors have the following disclosures:

David L. Kendler has served as an investigator for Merck, Amgen, Eli Lilly, Novartis, Takeda, GlaxoSmithKline, Pfizer, Servier, Biosante, and Wyeth, and a speaker, consultant, or advisor for and/or received honoraria from Merck, Amgen, Eli Lilly, Novartis, Servier, Nycomed, and Wyeth.

Louis Bessette has served as an investigator and advisory board member for Amgen.

Deborah Gold has served as a consultant for Amgen, Procter & Gamble, GlaxoSmithKline, F. Hoffman-La Roche Ltd., Sanofi-Aventis, Roche Diagnostics, Eli Lilly, and Merck. Additionally, she has received travel grants, speaking or writing fees, or other honoraria, and has served as a member of an advisory board for Amgen, Procter & Gamble, GlaxoSmithKline, F. Hoffman-La Roche Ltd., Sanofi-Aventis, Roche Diagnostics, and Eli Lilly.

Rob Horne has received unrestricted grants to the University of London from Procter & Gamble, Gilead Life Sciences, and Hayward Medical Communications/Shire Pharmaceuticals. Professor Horne also has conducted occasional paid consultancy, medical education lectures, and advisory committees for Abbott, Adelphi, Amgen, Astellas, Astrazeneca, Boehringer Ingelheim, Gilead, GlaxoSmithKlein, Hayward Medical Communications, Merck Outcomes Research, Novartis, Pfizer, Procter & Gamble, and Shire Pharmaceuticals. Some consultancies included travel and accommodations paid by pharmaceutical companies.

Cheryl D. Hill is a paid consultant for Amgen Inc.

Sepideh Farivar-Varon is a former employee of Amgen and current employee of Allergan Inc. Dr. Varon owns stock and/or stock options in both Amgen and Allergan Inc.

Jeff Borenstein, Rachel Wagman, Suresh Siddhanti, David Macarios, Huei Wang, and Hoi-Shen Man are employees and shareholders of Amgen.

Henry G. Bone has served as an investigator for Amgen, Eli Lilly, Merck, Nordic Biosciences, and Zelos; as a consultant for Amgen, Merck, Nordic Bioscience, Osteologix, Pfizer, and Zelos; and has received speaker honoraria from Merck and Novartis.

Supplementary material

198_2009_1023_MOESM1_ESM.doc (44 kb)
Supplementary Table 1 PSQ responses by language and country for the questions: “Which do you prefer?” and “With which frequency of administration have you been more satisfied?” (DOC 44 kb)


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  • D. L. Kendler
    • 1
  • L. Bessette
    • 2
  • C. D. Hill
    • 3
  • D. T. Gold
    • 4
  • R. Horne
    • 5
  • S. F. Varon
    • 6
    • 7
  • J. Borenstein
    • 7
  • H. Wang
    • 7
  • H.-S. Man
    • 8
  • R. B. Wagman
    • 9
    • 10
  • S. Siddhanti
    • 7
  • D. Macarios
    • 7
  • H. G. Bone
    • 11
  1. 1.Prohealth Clinical ResearchUniversity of British ColumbiaVancouverCanada
  2. 2.Le Centre Hospitalier Universitaire de QuébecPavillon CHULQuebec CityCanada
  3. 3.RTI Health SolutionsRTI InternationalResearch Triangle ParkUSA
  4. 4.Center for AgingDuke University Medical CenterDurhamUSA
  5. 5.Centre for Behavioral Medicine, The School of PharmacyUniversity of LondonLondonUK
  6. 6.AllerganIrvineUSA
  7. 7.Amgen Inc.Thousand OaksUSA
  8. 8.Amgen Inc.CambridgeUK
  9. 9.Amgen Inc.South San FranciscoUSA
  10. 10.Stanford University School of MedicineStanfordUSA
  11. 11.Michigan Bone and Mineral Clinic, P.C.DetroitUSA

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