Osteoporosis International

, Volume 21, Issue 3, pp 457–466

Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS)

  • R. Barr
  • H. Macdonald
  • A. Stewart
  • F. McGuigan
  • A. Rogers
  • R. Eastell
  • D. Felsenberg
  • C. Glüer
  • C. Roux
  • D. M. Reid
Original Article

Abstract

Summary

Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.

Introduction

Fall prevention is a key strategy for reducing osteoporotic fractures. It has been suggested that vitamin D supplementation may reduce the incidence of falls by reducing body sway and increasing muscle power. The vitamin D receptor gene is a well-studied candidate gene for osteoporosis. We investigated the association between VDR polymorphisms and reported falls in postmenopausal women.

Methods

Falls data were collected in two separate population cohorts. Five polymorphisms of the VDR gene were analysed (Cdx-2, Fok-1, BsmI, Taq1 and Apa1) in the Aberdeen Prospective Osteoporosis Screening Study (APOSS) cohort. Results found in APOSS were then validated in an independent cohort—the Osteoporosis and Ultrasound (OPUS) study (Bsm1 and Fok1 only), where muscle power and balance were also measured.

Results

Carriers of the ‘B’ allele (Bsm1) showed an increased risk for falls. In APOSS, this was statistically significant for visit 3 multiple falls (p = 0.047) and for recurrent falls (p = 0.043). Similar results were found in OPUS for visit 1 falls (p = 0.025) and visit 1 multiple falls (p = 0.015). Bsm1 polymorphisms were also associated with balance and muscle power measurements.

Conclusions

In conclusion, these results demonstrate an association between the Bsm1 polymorphism and risk of falling that may explain some of the excess fracture risk associated with VDR in some studies.

Keywords

Balance Falls Muscle power Vitamin D receptor gene 

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  • R. Barr
    • 1
  • H. Macdonald
    • 1
  • A. Stewart
    • 1
  • F. McGuigan
    • 1
    • 6
  • A. Rogers
    • 2
  • R. Eastell
    • 2
  • D. Felsenberg
    • 3
  • C. Glüer
    • 4
  • C. Roux
    • 5
  • D. M. Reid
    • 1
    • 7
  1. 1.Bone and Musculoskeletal Research ProgrammeUniversity of AberdeenAberdeenUK
  2. 2.Academic Unit of Bone Metabolism, School of Medicine and Biomedical SciencesUniversity of SheffieldSheffieldUK
  3. 3.Centre Muscle & Bone Research, Charité-Campus Benjamin FranklinFree University and Humboldt UniversityBerlinGermany
  4. 4.Medizinische Physik, Klinik für Diagnostische RadiologieUniversitätsklinikum Schleswig-Holstein, Campus KielKielGermany
  5. 5.Centre d’Evaluation des Maladies Osseuses, Service de Rhumatologie, Hôpital CochinUniversité René DescartesParisFrance
  6. 6.Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences MalmöLund UniversityMalmöSweden
  7. 7.Division of Applied MedicineUniversity of AberdeenAberdeenUK

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