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Osteoporosis International

, Volume 21, Issue 5, pp 765–772 | Cite as

A survey of bone mineral density of healthy Han adults in China

  • H. Zhu
  • J. Fang
  • X. Luo
  • W. Yu
  • Y. Zhao
  • X. Li
  • J. Du
  • Y. Lu
Original Article

Abstract

Summary

A recent survey of bone mineral density (BMD) in China recruited 7,042 healthy Han Chinese aged 20 years and older. The mean BMDs were different in gender, age, and region; the proportions of men and women older than 50 years with a high risk of osteoporosis were estimated as 10.4% and 31.2%, respectively

Introduction

A survey of BMD was completed during 2002–2006 in China. By three-stage sampling, a total of 7,042 healthy Han Chinese aged 20 years and older were recruited in ten cities: 2,694 subjects from Beijing, Tianjin, Haerbin, Lanzhou, and Yantai of northern China and 4,348 from Shanghai, Changsha, Chengdu, Haikou, and Foshan of southern China.

Methods

Two dual X-ray absorptiometry (DXA) systems (Hologic and Lunar) were used with parallel measurements of the European spine phantoms in each center. The mean BMDs in age groups older than 50 and the peak bone mineral density (pBMD) at femoral neck and that at greater trochanter were higher for men than women, and the pBMDs for northern China were higher than those for southern China, ranging from 1% to 4%.

Discussion and conclusion

This work has provided two useful references for the first time: one is the estimation of the proportion and number of individuals older than 50 years with a high risk of osteoporosis, 10.4% and 12.5 million men, 31.2% and 37.2 million women, which is important for health care planning and marketing projections, and another is the conversion equations for cross-calibration among different types of DXA instruments frequently used in China.

Keywords

Chinese National survey Osteoporosis Peak bone mineral density T-score 

Notes

Acknowledgment

We sincerely thank the Ministry of Health, People's Republic of China for the approval and guidance of this project. In addition to the authors of this paper, we appreciate the following colleagues who generously contributed to this project: SUN Tiansheng (Orthopedic Department of Beijing Army General Hospital), TAO Tianzun (The Second Affiliated Hospital of Harbin Medical University), CAO Haiwei (Foshan Chinese Tradition Medical Hospital), WANG Li (Tianjing Hospital), QIN Linlin (China–Japan Friendship Hospital), DENG Hongwen (Life Science Department of Hunan Normal University), ZHANG Shou and CHEN Wenyuan (Haikou Municipal Hospital), XIA Yayi (The Second Hospital of Lanzhou University), HU Zhenming (Beijing Friendship Hospital, Capital Medical University), ZHANG Shudong (Yantai City Yantai Shan Hospital), LI Jing (First Hospital of Peking University), SHI Huipeng (Shanghai 6th Peoples Hospital of Jiaotong University), and ZHU Xiaoying (Clinical and Research Center on Osteoporosis, East China Hospital, Fu Dan University).

Conflicts of interest

None.

References

  1. 1.
    WHO Scientific Group (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO technical report series 843, Geneva, SwitzerlandGoogle Scholar
  2. 2.
    WHO (1998) WHO guidelines for preclinical evaluation and clinical trials in osteoporosis. Geneva, SwitzerlandGoogle Scholar
  3. 3.
    WHO Scientific Group (2003) Prevention and management of osteoporosis. WHO technical report series 921, Geneva, SwitzerlandGoogle Scholar
  4. 4.
    Li NH, Ou PZ, Zhu HM, Yan DZ, Zen PR (2001) Prevalence of primary osteoporosis in the middle aged and elderly population in parts of China. Chinese J Orthop 21(5):275–278Google Scholar
  5. 5.
    Wu XP, Liao EY, Zhang H, Shan PF, Cao XZ, Liu SP (2004) Establishment of BMD reference plots and determination of peak BMD at multiple skeletal regions in mainland Chinese women and the diagnosis of osteoporosis. Osteoporos Int 15(1):71–79CrossRefPubMedGoogle Scholar
  6. 6.
    Zhang ZL, Qin YJ, Huang QR, Hu YQ, Li M, He JW, Zhang H, Liu YJ, Hu WW (2006) Bone mineral density of the spine and femur in healthy Chinese men. Asian J Androl 8(4):419–427CrossRefPubMedGoogle Scholar
  7. 7.
    Cheng XG, Yang DZ, Zhou Q, Zhuo TJ, Zhang HC, Xiang J, Wang HF, Ou PZ, Liu JL, Xu L, Huang GY, Huang QR, Barden HS, Weynand LS, Faulkner KG, Meng XW (2007) Age-related bone mineral density, bone loss rate, prevalence of osteoporosis, and reference database of women at multiple centers in China. J Clin Densitom 10(3):276–284CrossRefPubMedGoogle Scholar
  8. 8.
    Lu Y, Ashwini KM, Barbara AB, Claus CGA, Steve W, Thomas PF, Michael DJ, Kim NA, Steven RC, Harry KG (1996) Dual X-ray absorptiometry quality control: comparison of visual examination and process-control charts. J Bone Miner Res 11:626–637CrossRefPubMedGoogle Scholar
  9. 9.
    Dequeker J, Reeve J, Pearson J et al (1993) Multicentre European COMAC-BME Study on the standardization of bone densitometry procedures. Technol Health Care 1:127–131Google Scholar
  10. 10.
    Pearson J, Ruegsegger P, Dequeker J et al (1994) European semi-anthropomorphic phantom for the cross-calibration of peripheral bone densitometers: assessment of precision, accuracy and stability. Bone Miner 27:109–120CrossRefPubMedGoogle Scholar
  11. 11.
    Population Census Office under the State Council, Department of Population Social, Science and Technology Statistics, National Bureau of Statistics of the People's Republic of China (2002) Tabulation on 2000 population census of the People's Republic of China, vol 1. China Statistics Press, BeijingGoogle Scholar
  12. 12.
    Genant HK, Grampp S, Gluer CC et al (1994) Universal standardization for dual X-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res 9:1503–1514CrossRefPubMedGoogle Scholar
  13. 13.
    Kalender WA (1992) A phantom for standardization and quality control in spinal bone mineral measurements by QCT and DXA: design considerations and specifications. Med Phys 19:583–586CrossRefPubMedGoogle Scholar
  14. 14.
    Xu L, Cummings SR, Qin M et al (1995) Vertebral osteoporosis of women in Beijing, China. Chin J Osteoporos 1(1):81–83Google Scholar
  15. 15.
    An Z, Dingzhuo Y, Zujun Z et al (2002) Epidemiology study of osteoporotic vertebral fractur. Chin J Osteoporos 8(1):82–83Google Scholar
  16. 16.
    Lee Ninghua, Ou Pinzhong, Zhu Hanmin et al (2001) Prevalence of primary osteoporosis in the middle aged and elderly population parts of China. Chin J Orthop 21(5):275–278Google Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  1. 1.Clinical and Research Center on Osteoporosis, East China HospitalFu Dan UniversityShanghaiChina
  2. 2.Department of Medical Statistics and Epidemiology, School of Public HealthSun Yat-Sen UniversityGuangzhouChina
  3. 3.Beijing Friendship HospitalCapital Medical UniversityBeijingChina
  4. 4.Department of RadiologyPeking Union Medical College HospitalBeijingChina
  5. 5.Women’s Health Center of Beijing United Family HospitalBeijingChina
  6. 6.Osteoporosis Foundation of China Health Promotion FoundationBeijingChina
  7. 7.Beijing Tuberculosis & Thoracic Tumor Research InstituteBeijingChina
  8. 8.Department of RadiologyUniversity of California San FranciscoSan FranciscoUSA

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