Osteoporosis International

, Volume 21, Issue 4, pp 597–607

Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism

  • G. Armbrecht
  • D. L. Belavý
  • U. Gast
  • M. Bongrazio
  • F. Touby
  • G. Beller
  • H. J. Roth
  • F. H. Perschel
  • J. Rittweger
  • D. Felsenberg
Original Article



During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation.


To investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints.


Twenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest.


Bone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (−1.8(0.9)%, p = 0.042) whereas the RVE group did not (−0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12).


The results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.


Bone turnover markers DXA Microgravity Re-ambulation Vibration exercise 


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  • G. Armbrecht
    • 1
  • D. L. Belavý
    • 1
  • U. Gast
    • 1
  • M. Bongrazio
    • 1
  • F. Touby
    • 1
  • G. Beller
    • 1
  • H. J. Roth
    • 2
  • F. H. Perschel
    • 3
  • J. Rittweger
    • 4
  • D. Felsenberg
    • 1
  1. 1.Zentrum für Muskel- und KnochenforschungCharité Campus Benjamin FranklinBerlinGermany
  2. 2.Labor Limbach, Abteilung für Endokrinologie und OnkologieHeidelbergGermany
  3. 3.Zentralinstitut für Laboratoriumsmedizin und PathobiochemieCharité Campus Benjamin FranklinBerlinGermany
  4. 4.Institute for Biomedical Research into Human Movement and HealthManchester Metropolitan UniversityManchesterUK

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