Osteoporosis International

, Volume 20, Issue 8, pp 1309–1320

Depression and low bone mineral density: a meta-analysis of epidemiologic studies

  • Q. Wu
  • J. H. Magnus
  • J. Liu
  • A. F. Bencaz
  • J. G. Hentz
Review

Abstract

Summary

The association between depression and loss of bone mineral density (BMD) has been reported inconsistently. This meta-analysis, which pooled results from 14 qualifying individual studies, found that depression was associated with a significantly decreased BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression.

Introduction

The reported association between depression and loss of BMD has been controversial. This meta-analysis was conducted to determine whether depression and BMD are associated and to identify the variation in some subgroups.

Methods

English-language articles published before October 2008 were used as the data source. A total of six case-controlled and eight cross-sectional studies met prestated inclusion criteria (N = 10,523). Information on study design, participant characteristics, measurements of BMD and depression, and control for potential confounders was abstracted independently by two investigators using a standardized protocol.

Results

Overall, depression was associated with a significant decrease in mean BMD of spine (−0.053 g/cm2 [95% confidence interval {CI} −0.087 to −0.018 g/cm2]) and hip (−0.052 g/cm2 [95% CI −0.083 to −0.022 g/cm2]). A substantially greater BMD decrease was observed in depressed women (−0.076 g/cm2 in spine; −0.059 g/cm2 in hip) and in cases of clinical depression (−0.074 g/cm2 in spine; −0.080 g/cm2 in hip).

Conclusion

Depression is associated with low BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression. Depression should be considered as an important risk factor for osteoporosis.

Keywords

Bone Bone density Depression Depressive disorder Meta-analysis Review 

Abbreviations

BMD

Bone mineral density

BMI

Body mass index

CI

Confidence interval

DSM

Diagnostic and Statistical Manual of Mental Disorders

ROI

Region of interest

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  • Q. Wu
    • 1
  • J. H. Magnus
    • 2
  • J. Liu
    • 4
  • A. F. Bencaz
    • 3
  • J. G. Hentz
    • 1
  1. 1.BiostatisticsMayo ClinicScottsdaleUSA
  2. 2.Department of Community of Sciences, School of Public Health and Tropical MedicineTulane UniversityNew OrleansUSA
  3. 3.Department of Biostatistics, School of Public Health and Tropical MedicineTulane UniversityNew OrleansUSA
  4. 4.College of Arts and LettersNorthern Arizona UniversityFlagstaffUSA

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