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An updated systematic review of Health State Utility Values for osteoporosis related conditions

  • T. Peasgood
  • K. Herrmann
  • J. A. Kanis
  • J. E. BrazierEmail author
Review

Abstract

Introduction

An important component of cost effectiveness models in the field of osteoporosis is the set of Health State Utility Values (HSUVs) used for key fracture outcomes. This paper presents a review of HSUVs for key osteoporotic states (hip, wrist, shoulder, clinical, and morphometric vertebral fractures, established osteoporosis, and interaction of several fractures). It provides an update to the systematic review conducted by Brazier et al. (Osteoporos Int 13(10):768–776, 2002).

Materials and methods

A systematic search was undertaken of the main literature databases for HSUVs for established osteoporosis, vertebral, hip, wrist, and shoulder fractures were identified. Studies meeting the inclusion criteria were reviewed in terms of the patient population, the method of describing health (if not obtained directly from patients), the method of valuing health states and the source of values.

Results

Estimates of Health State Utility Values were found across the osteoporosis conditions from 27 studies. A wide range of empirical estimates were found, partly due to differences in valuation technique (VAS, SG, TTO), descriptive system and differences in respondents (population or patient), the perspective of the task (own health or a scenario), sample size, and study quality.

Conclusion

The paper provides a set of multipliers representing the loss in HSUVs for use as a “reference case” in cost-effectiveness models.

Keywords

Health State Utility Values Osteoporosis Quality adjusted life years Utilities 

Notes

Funding

This study review was funded by Lilly. John Brazier is funded by the UK Medical Research Council.

Supplementary material

198_2009_844_MOESM1_ESM.doc (195 kb)
APPENDIX A (DOC 195 kb)
198_2009_844_MOESM2_ESM.doc (642 kb)
APPENDIX B (DOC 642 kb)

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  • T. Peasgood
    • 1
  • K. Herrmann
    • 1
  • J. A. Kanis
    • 2
  • J. E. Brazier
    • 1
    Email author
  1. 1.Health Economics and Decision Science, School of Health and Related ResearchUniversity of Sheffield Regent CourtSheffieldUK
  2. 2.WHO Collaborating Centre for Metabolic Bone DiseasesUniversity of SheffieldSheffieldUK

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