Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women
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Remaining lifetime and absolute 10-year probabilities for osteoporotic fractures were determined by gender, age, and BMD values. Remaining lifetime probability at age 50 years was 20.2% in men and 51.3% in women and increased with advancing age and decreasing BMD. The study validates the elements required to populate a Swiss-specific FRAX® model.
Switzerland belongs to high-risk countries for osteoporosis. Based on demographic projections, burden will still increase. We assessed remaining lifetime and absolute 10-year probabilities for osteoporotic fractures by gender, age and BMD in order to populate FRAX® algorithm for Switzerland.
Osteoporotic fracture incidence was determined from national epidemiological data for hospitalised fractured patients from the Swiss Federal Office of Statistics in 2000 and results of a prospective Swiss cohort with almost 5,000 fractured patients in 2006. Validated BMD-associated fracture risk was used together with national death incidence and risk tables to determine remaining lifetime and absolute 10-year fracture probabilities for hip and major osteoporotic (hip, spine, distal radius, proximal humerus) fractures.
Major osteoporotic fractures incidence was 773 and 2,078 per 100,000 men and women aged 50 and older. Corresponding remaining lifetime probabilities at age 50 were 20.2% and 51.3%. Hospitalisation for clinical spine, distal radius, and proximal humerus fractures reached 25%, 30% and 50%, respectively. Absolute 10-year probability of osteoporotic fracture increased with advancing age and decreasing BMD and was higher in women than in men.
This study validates the elements required to populate a Swiss-specific FRAX® model, a country at highest risk for osteoporotic fractures.
KeywordsAbsolute 10-year fracture probability FRAX® Hospitalisation rate Incidence Osteoporotic fractures Remaining lifetime probability
We are grateful to Dr Philippe Kress for his contribution to the writing of the manuscript.
Conflicts of interest
- 13.Kanis J (2007) World health organization scientific group. assessment of osteoporosis at the primary health care level. Technical report. World Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UKGoogle Scholar
- 16.Suhm N, Lamy O, Lippuner K (2008) Management of fragility fractures in Switzerland: results of a nationwide survey. Swiss Med Wkly Oct 14. [Epub ahead of print]Google Scholar
- 17.United Nations population division (2003). World population prospects: the 2002 revision and world urban prospects. Population division of the Dept Economic and Social Affairs of the UN Secretariat.Google Scholar
- 25.Mathers CD, Murray CJL, Lopez AD, et al. (2001) World Health Organization Global Programme on Evidence for Health Policy Discussion Paper No. 38 http://www.who.int/healthinfo/paper38.pdf. Last visited May 13, 2006.
- 27.Bundesamt für Statistik. Szenarien zur Bevölkerungsentwicklung der Schweiz 2005–2050. http://www.bfs.admin.ch/bfs/portal/de/index/news/publikationen.Document.83713.pdf. Last visited May 14, 2008
- 33.SEER Cancer Statistics Review, 1975–2004 (NCI 2007). Cancer Facts and Figures 2007, American Cancer Society. http://seer.cancer.gov/csr/1975_2005/results_merged/topic_lifetime_risk.pdf. Last visited May 15, 2008.
- 40.Committee for Medicinal Products for Human Use (CHMP). Guideline on the evaluation of medicinal products in the treatment of primary osteoporosis. Ref CPMP/EWP/552/95Rev.2. London, CHMP. Nov 2006Google Scholar
- 43.Krieg MA, Cornuz J, Ruffieux C et al (2006) Prediction of hip fracture risk by quantitative ultrasound in more than 7000 Swiss women > or = 70 years of age: comparison of three technologically different bone ultrasound devices in the SEMOF study. J Bone Miner Res 21:1457–1463PubMedCrossRefGoogle Scholar