Sequential change in quality of life for patients with incident clinical fractures: a prospective study
Health-related quality of life in elderly women with sustained incident fractures was assessed prospectively for 1 year, using the EuroQol standard. Loss of QOL was more severe in patients after hip or vertebral fractures than those with wrist fracture. QOL was not completely restored in patients suffering from hip fracture.
Osteoporosis-related fractures decrease mobility, social interaction, and emotional well-being. All of these characteristics determine health-related quality of life (HR-QOL). In this study, we assessed HR-QOL in elderly women following incident clinical fractures.
Thirty-seven patients with hip fractures (mean age 76.1 years), 35 with vertebral fractures (mean age 72.6 years), and 50 with wrist fractures (mean age 68.6 years) were enrolled. HR-QOL was prospectively measured using EuroQol (EQ-5D) before the fracture, 2 weeks, 3 months, 6 months, and 1 year after the fracture.
During the observation period, reduction of EQ-5D values was greatest in the hip fracture group. In the wrist fracture group, EQ-5D values at 6 months after the fracture showed recovery; however, in the hip and vertebral fracture groups, recovery was significantly lower than before the fracture. One year after the fracture, EQ-5D values were not significantly different from prefracture values in the vertebral and wrist fracture groups, but remained significantly lower in the hip fracture group.
Loss of QOL was more severe in patients after hip or vertebral fractures than in patients with wrist fracture. HR-QOL was not completely restored in patients suffering from hip fracture.
KeywordsHip fracture Quality of life Vertebral fracture Wrist fracture
- 14.Ikeda S, Ikegami N (2001) Preference-based measure(EQ-5D) In: Ikegami N, Fukuhara S, Shimozuma K, Ikeda S (eds) QOL evaluation handbook for clinical practice(in Japanese). Igakushoin, Tokyo, pp 14–18Google Scholar
- 15.Ikeda S, Ikegami N (1999) Health status in Japanese population: results from Japanese EuroQol study. Iryou to Shakai 9:83–92Google Scholar
- 16.Nawata S, Yamad Y, Ikeda S et al (2000) EuroQol study of the elderly general population: Relationship with IADL and other attributes. Iryou to Shakai (in Japanese) 10:75–86Google Scholar
- 29.Lips P, Cooper C, Agnusdei D et al (1999) Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int 10:150–160PubMedCrossRefGoogle Scholar
- 30.NOF (1998) Osteoporosis: review of the evidence for prevention, diagnosis and treatment and cost-effectiveness analysis. Introduction. Osteoporos Int 8(Suppl 4):S7–S80Google Scholar