Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae
- First Online:
This study investigated regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. The results demonstrate that age-related changes in trabecular microstructure significantly varied from different sub-regions of the proximal femur.
We hypothesize that the age-related changes in trabecular bone microstructure appear to be varied from specific anatomic sub-regions of the proximal femur followed by non-uniform bone loss. The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging.
A total of 162 trabecular bone cores from six regions of 27 femora of male cadaver donors were scanned using micro-computed tomography (micro-CT). The following microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp), structure model index (SMI), and degree of anisotropy (DOA).
Age-related changes in trabecular microstructure varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference in BV/TV, Tb.Th, Tb.Sp, Tb.N and DOA between superior and inferior neck, as well as a significant difference in BV/TV, Tb.Sp, Tb.N, SMI and DOA between superior and inferior trochanter.
Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this cadaveric population.
KeywordsAging Microstructure Proximal femur Trabeculae
- 3.Siddiqui NA (1999) Osteoporosis in older men: discovering when and how to treat it. Geriatrics 54:21–32Google Scholar
- 15.NIH Consens Statement (2000) Osteoporosis prevention, diagnosis, and therapy No.17:1–45Google Scholar