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Osteoporosis International

, Volume 19, Issue 9, pp 1277–1282 | Cite as

Association of Parkinson’s disease with accelerated bone loss, fractures and mortality in older men: the Osteoporotic Fractures in Men (MrOS) study

  • H. A. FinkEmail author
  • M. A. Kuskowski
  • B. C. Taylor
  • J. T. Schousboe
  • E. S. Orwoll
  • K. E. Ensrud
  • for the Osteoporotic Fractures in Men (MrOS) Study Group
Original Article

Abstract

Summary

Among community-dwelling older men, compared to those without Parkinson’s disease (PD), over approximately 5 years, those with baseline PD had a significantly greater rate of annualized total hip bone loss (−1.1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%).

Introduction

The objective of this study was to examine the association of Parkinson’s disease (PD) with bone loss and fractures in older men.

Methods

This prospective cohort study analyzed data from 5,937 community dwelling men aged ≥65 years at six clinical centers of the Osteoporotic Fractures in Men (MrOS) Study. At baseline and visit two (mean interval 4.6 +/−0.4 SD years), community-diagnosed PD was ascertained by self-report and hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry (DXA). Incident fractures were self-reported. Fractures and deaths were centrally adjudicated.

Results

At baseline, 46 (0.8%) men had PD. Age-adjusted mean annualized total hip bone loss was greater in men with vs. those without PD (−1.08% vs. −0.36%, p < 0.001). 15.2% of men with PD and 7.2% of men without PD experienced an incident non-spine fracture (age-adjusted HR 2.4, 95%CI 1.1–5.0). 34.8% of men with PD and 9.5% of men without PD died during follow-up (age-adjusted HR 3.5, 95%CI 2.2–5.5). Associations of PD with bone loss, fractures and mortality were modestly altered by additional individual adjustment for possible confounders.

Conclusions

In community-dwelling older men, PD was associated with increased bone loss, fractures and mortality. In addition to implementing fall prevention measures, clinicians should consider osteoporosis screening in older men with PD.

Keywords

Bone density Fractures Mortality Osteoporosis Parkinson’s disease 

Notes

Potential financial conflicts of interest

Dr. Schousboe receives research grant support from Hologic, Inc. Dr. Ensrud receives research grant support from Bionovo. Dr. Orwoll receives research, consulting or speaking support from Aventis, Pfizer, Eli Lilly & Co., Novartis, Merck & Co., Procter & Gamble, GlaxoSmithKline, Zelos Therapeutics Inc., Imaging Therapeutics Ind., and Solvay Pharmaceuticals. All other authors have no conflicts of interest.

Author contributions

Conception and design: H.A. Fink, M.A. Kuskowski

Acquisition of participants and/or data: E.S. Orwoll, K.E. Ensrud

Analysis and interpretation of the data: H.A. Fink, M.A. Kuskowski, B.C. Taylor, J.T. Schousboe, K.E. Ensrud

Drafting of the article: H.A. Fink

Critical revision of the article for important intellectual content: H.A. Fink, M.A. Kuskowski, B.C. Taylor, J.T. Schousboe, E.S. Orwoll, K.E. Ensrud

Final approval of the article: H.A. Fink, M.A. Kuskowski, B.C. Taylor, J.T. Schousboe, E.S. Orwoll, K.E. Ensrud

Sponsor’s role

The funding agencies played no role in the design, analysis and preparation of this manuscript.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2008

Authors and Affiliations

  • H. A. Fink
    • 1
    • 2
    • 3
    • 4
    • 8
    Email author
  • M. A. Kuskowski
    • 1
  • B. C. Taylor
    • 2
    • 4
  • J. T. Schousboe
    • 5
    • 6
  • E. S. Orwoll
    • 7
  • K. E. Ensrud
    • 2
    • 3
    • 4
  • for the Osteoporotic Fractures in Men (MrOS) Study Group
  1. 1.Geriatric Research Education and Clinical CenterVA Medical CenterMinneapolisUSA
  2. 2.Center for Chronic Disease Outcomes ResearchVA Medical CenterMinneapolisUSA
  3. 3.Department of MedicineUniversity of MinnesotaMinneapolisUSA
  4. 4.Division of Epidemiology, School of Public HealthUniversity of MinnesotaMinneapolisUSA
  5. 5.Division of Health Services Research and Policy, School of Public HealthUniversity of MinnesotaMinneapolisUSA
  6. 6.Division of RheumatologyPark Nicollet Health ServicesMinneapolisUSA
  7. 7.Bone and Mineral UnitOregon Health & Science UniversityPortlandUSA
  8. 8.VA Medical CenterMinneapolisUSA

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