Dietary protein intake and bone mineral content in adolescents—The Copenhagen Cohort Study
- First Online:
- 167 Downloads
Data indicate that various protein sources may exhibit a differential effect on bone metabolism. We investigated associations of milk and meat protein intake with bone mineral content (BMC) in adolescents. Milk, but not meat, protein intake was positively associated with size-adjusted BMC. Milk-derived protein may be beneficial for bone mineralization.
Milk and meat protein intake has been reported to exhibit a differential effect on serum insulin-like growth factor-I (IGF-I). IGF-I plays a key role in bone metabolism. Therefore, we investigated associations of different protein sources with BMC and bone area (BA) in adolescents.
This was a cross-sectional study of 17-year-old girls (n = 63) and boys (n = 46) participating in the second follow-up of The Copenhagen Cohort Study. We measured dietary intake (7-day food record), BMC and BA (dual-energy X-ray absorptiometry), serum markers for bone turnover and serum IGF-I (immunoassays).
The mean total protein intake (∼1.2 g/kg) was modestly higher than that recommended. Total and milk (∼0.3 g/kg) protein intake, but not meat protein intake (∼0.4 g/kg), was positively associated with size-adjusted BMC (P ≤ 0.05). The positive association between milk protein intake and size-adjusted BMC remained significant after correction for energy, calcium, and physical activity (P ≤ 0.01) and did not seem to be mediated via current serum IGF-I. None of the analyzed protein sources was significantly associated with size-adjusted BA.
Our results suggest that some components of milk protein may promote bone mineralization. Further studies are needed to elucidate this phenomenon.
KeywordsBMC Diet Growth Meat protein Milk protein
- 18.Alexander J, Andressen SA, Aro A, Becker W, Lyhne N, Meltzer HM, Pedersen AN, Pedersen JI, Porsdottir I (eds) (2004) Nordic nutrition recommendations. Integrating nutrition and physical activity. Norden. ÅrhusGoogle Scholar
- 20.Juul A, Dalgaard P, Blum WF, Bang P, Hall K, Michaelsen KF, Muller J, Skakkebaek NE (1995) Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab 80:2534–2542PubMedCrossRefGoogle Scholar
- 23.Lloyd T, Rollings N, Andon MB, Demers LM, Eggli DF, Kieselhorst K, Kulin H, Landis JR, Martel JK, Orr G, (1992) Determinants of bone density in young women. I. Relationships among pubertal development, total body bone mass, and total body bone density in premenarchal females. J Clin Endocrinol Metab 75:383–387PubMedCrossRefGoogle Scholar
- 29.Budek AZ, Hoppe C, Michaelsen KF, Mølgaard C (2007) High intake of milk, but not meat, decreases bone turnover in prepubertal boys after 7 days. Eur J Clin Nutr DOI 10.1038/sj.ejcn.1602605
- 34.Zimecki M, Artym J (2005) Therapeutic properties of proteins and peptides from colostrum and milk (in Polish with English abstract). Postepy Hig Med Dosw 59:309–323Google Scholar