Osteoporosis International

, 18:1189

β-blocker use and risk of fractures in men and women from the general population: the MONICA/KORA Augsburg cohort study

Original Article

DOI: 10.1007/s00198-007-0354-8

Cite this article as:
Meisinger, C., Heier, M., Lang, O. et al. Osteoporos Int (2007) 18: 1189. doi:10.1007/s00198-007-0354-8



Use of β-blockers is associated with a reduced risk of fractures in middle-aged and older subjects from the general population.


The present prospective population-based study investigated the association between use of β-blockers and incidence of any fracture.


The study was based on 1,793 persons 55 to 74 years of age who participated in one of the three MONICA Augsburg surveys between 1984 and 1995. Subjects were without any fracture at baseline. Incident fractures were assessed using a health questionnaire. Hazard ratios (HRs) were estimated from Cox proportional hazard models.


During a mean follow-up of 10.7 years, there occurred 263 incident fractures. β-blocker users were older, were significantly more likely to be obese, to drink no alcohol, to have hypertension or diabetes, to use thiazides and statins, and to be physically inactive. The use of β-blockers was associated with a lower risk of any fracture (HR 0.57; 95% CI = 0.36–0.90) after adjustment for age, sex and survey. Further adjustment for body mass index and education years only slightly attenuated the relationship (HR 0.60; 95% CI = 0.38–0.95) and additional adjustment for a variety of further risk factors did not attenuate the association (HR 0.60; 95% CI = 0.37–0.96).


Use of β-blockers was associated with a reduced risk of fractures in middle-aged and older subjects from the general population.


Aging Epidemiology Osteoporosis Population studies Treatments 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2007

Authors and Affiliations

  1. 1.Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction RegistryAugsburgGermany
  2. 2.GSF National Research Center for Environment and Health, Institute of EpidemiologyNeuherbergGermany

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