Effectiveness of bisphosphonates on nonvertebral and hip fractures in the first year of therapy: The risedronate and alendronate (REAL) cohort study
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- Silverman, S.L., Watts, N.B., Delmas, P.D. et al. Osteoporos Int (2007) 18: 25. doi:10.1007/s00198-006-0274-z
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Randomized clinical trials have shown that risedronate and alendronate reduce fractures among women with osteoporosis. The aim of this observational study was to observe, in clinical practice, the incidence of hip and nonvertebral fractures among women in the year following initiation of once-a-week dosing of either risedronate or alendronate.
Using records of health service utilization from July 2002 through September 2004, we created two cohorts: women (ages 65 and over) receiving risedronate (n = 12,215) or alendronate (n = 21,615). Cox proportional hazard modeling was used to compare the annual incidence of nonvertebral fractures and of hip fractures between cohorts, adjusting for potential differences in risk factors for fractures.
There were 507 nonvertebral fractures and 109 hip fractures. Through one year of therapy, the incidence of nonvertebral fractures in the risedronate cohort (2.0%) was 18% lower (95% CI 2% – 32%) than in the alendronate cohort (2.3%). The incidence of hip fractures in the risedronate cohort (0.4%) was 43% lower (95% CI 13% – 63%) than in the alendronate cohort (0.6%). These results were consistent across a number of sensitivity analyses.
Patients receiving risedronate have lower rates of hip and nonvertebral fractures during their first year of therapy than patients receiving alendronate.
KeywordsBisphosphonates Epidemiology Hip fractures Nonvertebral fractures Osteoporosis
Osteoporosis, a common skeletal disease in older populations, leads to more than a million fractures annually in the United States . Nonvertebral fractures represent 75% of osteoporotic fractures seen in clinical practice . The incidence of nonvertebral fractures, especially at the hip, increases rapidly with age . In order to prevent these fractures, US clinical guidelines recommend that candidates for osteoporosis therapy be identified by screening the bone mineral density of all woman ages 65 and over (age 60 for high risk populations) .
Oral bisphosphonates are currently the most common therapy for osteoporosis . While the three most utilized bisphosphonates (alendronate, risedronate, ibandronate) approved by the Food and Drug Administration have been shown to reduce vertebral fractures in randomized clinical trials, it is unknown if these three are equally effective in reducing nonvertebral fractures of real-world patients in clinical practice. A comparison of the results from the randomized clinical trials of each bisphosphonate, though limited by methodological differences between trials, suggests potential differences in degree of fracture reduction across bisphosphonates. In the primary analyses of the trials that followed patients for at least 3 years, risedronate significantly reduced the incidence of nonvertebral fractures by up to 39% [6, 7]; alendronate reduced the incidence of nonvertebral fractures by up to 21% [8, 9, 10]; ibandronate did not reduce nonvertebral fractures . Post-hoc analyses of these trial data suggest that there are differences in the onset of fracture reduction. In those analyses, reduction of nonvertebral fractures began at 6 months for 5 mg daily dosing of risedronate  and at either 12 months (when fractures were recorded as adverse events) for 10 mg daily dosing of alendronate  or 24 months for 5 mg daily dosing of alendronate . These possible differences in both the amount and the onset of fracture reduction between the bisphosphonates could arise from their differences in structure, potency, and binding properties .
The only direct comparison of bisphosphonates in a randomized clinical trial is based on surrogate endpoints (e.g., changes in bone mineral density and markers of bone turnover) . However, the association between changes in these surrogates and subsequent fracture reduction is not consistent across studies [17, 18]. Unlike randomized clinical trials based on surrogate endpoints, observational studies of large populations provide the opportunity to use major disease endpoints (e.g., hip fracture) as the outcome of interest. The limitation of observational studies can be misleading results from bias arising from non-randomized treatment groups. This bias can be accounted for in part by statistically adjusting for known risk differences between groups. Furthermore, when different therapies are available to be prescribed for the same indication, there is at least some expectation of similarity in prognostic factors between treatment groups occurring naturally . For example, observational studies have compared both the many antihypertensive drug therapies and many statins for reducing the disease endpoint of myocardial infarctions [20, 21].
Since the once-a-week dosing regimens of both risedronate and alendronate have been available in the US since 2002, there is now an opportunity to observe their effect on reducing fractures in a large population of patients seen in clinical practice. Hence, we conducted an observational study across multiple US health plans to observe the incidence of hip and nonvertebral fractures among women ages 65 and over following initiation of therapy with once-a-week dosing of either risedronate or alendronate.
The RisedronatE and ALendronate (REAL) cohort study was a retrospective observation of bisphosphonate patients within healthcare utilization records in the United States. The analysis plan was based upon an earlier report . All authors had access to the data. For assurance of reproducibility , the analyses were independently replicated by the respective organizations of the authors. The reporting of this study is consistent with the STROBE guidelines .
The data source was commercially available datasets of healthcare utilization from the 1 health plan within Ingenix Lab/Rx (Eden Prairie, MN; data through June 2004) and the 100 health plans of employers within MedStat Marketscan (Ann Arbor, MI; data through September 2004). These datasets contain a longitudinal history of patient-specific data including demographic information (sex, age, dates of dataset inclusion), clinical encounters (inpatient and outpatient services by associated procedures and diagnoses specified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM)), and outpatient pharmaceutical dispensations (retail and mail order specified by the national drug code (NDC)). To maximize sample size, the two datasets were combined for all analyses. At the time of data extraction for the current study, the combined datasets contained 12 million persons across 34 states in the US.
Length of observation
Observation for a subject was censored at one of following end points, whichever occurred first: date of fracture, 12 months after date of first bisphosphonate prescription, end date of health plan enrollment, date of switch between bisphosphonate therapies or end date of therapy adherence. Adherence was measured as a function of the gaps between refills, which provides the best available measure within datasets of medical claims . Once the gap between the completion of a 30-day supply and the start of a new prescription exceeded 15 days, the end date of therapy adherence was the prescription date before gap plus 45 days. For a 90-day supply, a gap of 45 days was allowed between completion and a new prescription, the end date of therapy adherence was the prescription date before gap plus 135 days. For the last prescription, the end date of therapy adherence was the date of last prescription plus 45 days for a 30-day supply and date of last prescription plus 135 days for a 90-day supply.
Identification of fractures outcomes in the study population (n = 33,830)
Subjects with a medical claim for fracture during the observation period after initial bisphosphonate.
Exclusion of medical claim if a fracture at the same site both before and after start of bisphosphonate therapy; in order to increase the likelihood of including only new fractures.
Exclusion of medical claim if a fracture at an unspecified sitec before the start of bisphosphonate therapy; in order to increase the likelihood of including only new fractures.
Exclusion of medical claim if an open fractured; in order to decrease the likelihood of including traumatic fractures.
Exclusion of medical claim if documented cause (E-codes) of injury is other than an accidental falle; in order to decrease the likelihood of including traumatic fractures.
Subjects with a fracture outcome
Comparison of baseline characteristics between cohorts in study
Number of women subjects
Duration of observation period
Age at study entry
Years & months (mean)
74 & 10
74 & 7
Ages 65 – 74 (%)
Ages 75 – 84 (%)
Ages 85 and over (%)
Medications – 6 month historya
Concomitant medications (mean)b
Gastrointestinal medication use (%)c
Estrogen use (%)d
Other non-estrogen anti-osteoporotic use (%)e
Glucocorticosteroid use (%)f
Medical encounters – 6 month historya
Office visits (mean)
Osteoporosis diagnosis (%)g
Osteopenia diagnosis (%)h
Bone densitometry procedure (%)i
Gastrointestinal diagnosis (%)j
Rheumatoid arthritis diagnosis (%)k
For the primary analysis, the main outcome measures were the 6 and 12 month incidence of nonvertebral fractures and hip fractures. Cox proportional hazard modeling (PROC PHREG, SAS Institute, Cary, NC) was used to compare the incidence of fractures between risedronate and alendronate cohorts, adjusting for potential differences in measurable risk factors for fractures. A parsimonious model for each outcome was developed to enhance precision of the parameter estimates and interpretation of results. The selection of variables to be included in the model was based on forward selection. These models were checked against models based on backward selection. The appropriateness of the proportional hazard assumption was assessed by graphical and numerical methods (ASSESS statement, SAS Institute).
In order to evaluate if the results of the primary analysis were dependent on methodology, sensitivity analysis were used to compare the incidence of fractures between risedronate and alendronate cohorts. These methods included: (1) an intent-to-treat analysis that observed all subjects for 12 months regardless of therapy adherence; (2) a proportional hazard model using the propensity score to adjust for differences in baseline fracture risk between cohorts; (3) use of different inclusion criteria for the study population; (4) use of different inclusion criteria for the study outcomes (see Fig. 5 for specifics).
During the 12 months of observation after the start of bisphosphonate therapy, 507 subjects had nonvertebral fractures. The site of nonvertebral fracture was wrist (30%), hip (21%), leg (17%), pelvis (15%), humerus (14%), and clavicle (3%). For the 109 women hospitalized with a hip fracture, the skeletal sites were intertrochanteric (46%), transcervical (28%), unspecified (20%), and trochanteric or subtrochanteric (6%).
Cumulative incidence of fractures during therapy
Number of women with a fracture
Percent of women with a fracturea
Crude rate ratiob
Adjusted rate ratiob
Time on therapy
In this observational study across multiple US health plans, we observed that patients on once-a-week dosing of risedronate had a lower incidence of hip and nonvertebral fractures than patients on once-a-week dosing of alendronate. Differences in fracture incidence between these two cohorts of patients were observed at 6 and 12 months after initiating therapy.
As with all observational studies, systematic errors (e.g., selection bias, measurement misclassification) may be the basis for the observed results . In this study, systematic errors may arise from differences in fracture risk between the 2 cohorts of patients at initiation of therapy. Between the two cohorts, there were statistical differences in measurable fracture risk characteristics (Table 2), there are likely to be differences in known fracture risk characteristics not available within medical claims data (e.g., bone mineral density, family history, smoking history), and there are likely to be differences in unknown fracture risk characteristics (i.e., those that are controlled through randomized trials). The differences in measurable fracture risk characteristics, for which a greater percentage of the risedronate cohort has risk factors for fracture than the alendronate cohort suggesting bias towards higher fracture rates in the risedronate cohort, are inconsistent with observed results. The near unity in fracture incidence between the two cohorts during the first 3 months of therapy (Figs. 3 and 4) - a period for which there is also unity in fracture incidence between bisphosphonate therapy and placebo in clinical trials [12, 14] - suggest that both cohorts had similar risk for fracture at initiation of therapy. However, differences in fracture risk at initiation of therapy between the two cohorts cannot be excluded.
Within healthcare utilization data, which are collected for purposes other than research, misclassification of fracture events and of therapy use are inevitable. As a check on the data, the rate of fracture events and therapy use of these health utilization data are in agreement with other data sources. In the current study, the annual fracture rates following initiation of therapy (≈2.0% for nonvertebral fractures and ≈0.5% for hip fractures) are consistent with the annual rates in the treated population of clinical trials (between 2.0 and 2.3% for nonvertebral fractures and between 0.4% and 0.7% for hip fractures [6, 7, 8, 9, 10, 27]). In this study, risedronate patients constituted 25% [45,360/(45,360 + 137,412)] of the bisphosphonate users in the utilization data compared to 24% [13.6 million / (13.6 million + 44.1 million)] of all bisphosphonate prescriptions in the US during the same period . A good method for evaluating misclassification within healthcare utilization data is through a medical chart review. In a prior study, the proportion of fracture claims confirmed by chart review to be a fracture was highest for the hip relative to other fracture sites . Since the effect of misclassification at these other fracture sites is likely to be no different between cohorts (i.e., misclassified exposure does not depend on cohort status), the study results for nonvertebral outcomes are likely more attenuated by misclassification than results for the hip .
The strength of observational studies can be the generalizability of results. In contrast, the generalizability of results from randomized trials to a real world setting can be limited by differences between the two in relation to expertise of health care provider, quality of medical care, course of therapy, and types of patients . For example, it has been observed that the majority of patients considered candidates for osteoporosis therapy by their physician would not meet the eligibility criteria for inclusion in the randomized trials . Since the population within the current observational study is drawn from multiple health plans in many US states and consists of subjects with a mixture of health characteristics (e.g., prior gastrointestinal comorbidities), the results are likely to be generalizable. Furthermore, the length of observation of therapy adherence (≈232 days) in the current study was consistent to the previously reported average duration of adherence to bisphosphonate therapy (245 days) .
In conclusion, within this observational study of clinical practice, a cohort of patients receiving risedronate had lower rates of hip and nonvertebral fractures during their first year of therapy than a cohort of patients receiving alendronate. These results do not appear to be explained by baseline differences in fracture risk between cohorts. In addition, the observed rates of fracture were consistent with the fracture rates in clinical trials. Thus it appears, patients receiving risedronate are better protected from hip and nonvertebral fractures during their first year of therapy than patients receiving alendronate.
Drs. Silverman, Watts, Delmas, and Lindsay have received consulting fees, lecture fees, or research grants from The Alliance for Better Bone Health (Procter & Gamble Pharmaceuticals and sanofi-aventis). Dr. Lange is an employee of Procter & Gamble Pharmaceuticals.
The data source for this article was leased by The Alliance for Better Bone Health. Every author had full access to all of the data and takes responsibility for the integrity of the data and the accuracy of the data analysis.