Osteoporosis International

, Volume 18, Issue 1, pp 93–99 | Cite as

Volumetric bone mineral density and bone size in sleep-deprived individuals

Original Article

Abstract

Introduction

Chronic sleep deprivation, which is associated with several age-related pathologies and altered endocrine function, may adversely affect bone. Our a priori hypothesis was that bone mineral density was lower in sleep-deprived (<6.5 h/night) vs. sleep-adequate (>6.5-10 h/night) individuals.

Methods

Cross-sectional analysis of sleep and bone data on 1,146 individuals (652 women) was performed. Measurements were obtained at the distal radius by pQCT, and the spine and hip by DXA. Bone differences between sleep-deprived and sleep-adequate groups were compared after stratifying by sex and controlling for covariates.

Results

Overall, 19% of the population was sleep deprived. Sleep-deprived women had lower cortical volumetric BMD (1,208±4 vs. 1,219±2 mg/cm3, P=0.03) than sleep-adequate women. Sleep-deprived men had lower pSSI, an estimate of torsional bending strength, than sleep-adequate men (358±10 vs. 382±5 mm3, P=0.04), due to a slightly smaller periosteal circumference (43.9±0.4 vs. 44.8±0.2 mm, P=0.07) and cortical area (103±2 vs. 106±1±mm2, P=0.06).

Conclusion

Sleep deprivation is associated with some, but not all, bone outcomes. These findings may have important public health significance given the increasing prevalence of sleep deprivation.

Keywords

Aging Body composition Bone density Bone size Sleep 

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2006

Authors and Affiliations

  • B. L. Specker
    • 1
  • T. Binkley
    • 1
  • M. Vukovich
    • 2
  • T. Beare
    • 1
  1. 1.EA Martin Program in Human NutritionEAM Bldg South Dakota State UniversityBrookingsUSA
  2. 2.Exercise Physiology LaboratorySouth Dakota State UniversityBrookingsUSA

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