Osteoporosis International

, Volume 17, Issue 2, pp 297–303

The determinants of bone mineral density in Chinese men—results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men

  • E. M. C. Lau
  • P. C. Leung
  • T. Kwok
  • J. Woo
  • H. Lynn
  • E. Orwoll
  • S. Cummings
  • J. Cauley
Original Article

Abstract

Mr. Os (Hong Kong) is the first study to address the risk factors for osteoporosis in Asian men. A standardized, structured interview and dual X-ray densitometry (DEXA) were performed on 2,000 Chinese men aged 65–92. By multiple regression, the following factors were found to be positively associated with BMD at both the total hip and the spine: body weight, grip strength and a history of diabetes mellitus. The following factors were found to be negatively associated with BMD at both the total hip and spine: cigarette smoking, a history of gastrectomy or bowel resection, current use of inhaled steroid and a history of fracture after 50 years. Moreover, a history of chronic obstructive pulmonary disease (COPD) was negatively associated with BMD at the total hip, and age, the use of an alpha-blocker, thiazide diuretic and nitrate were associated with a higher BMD at the spine. A total of 21.8% of the variance in total hip and 31.5% of the variance in total spine BMD was accounted for in the multivariate analysis.

Keywords

Asian men Cigarette smoking Corticosteroid Medical factors Osteoporosis 

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • E. M. C. Lau
    • 1
  • P. C. Leung
    • 2
  • T. Kwok
    • 3
  • J. Woo
    • 3
  • H. Lynn
    • 4
  • E. Orwoll
    • 5
  • S. Cummings
    • 6
  • J. Cauley
    • 7
  1. 1.Hong Kong Orthopaedic and Osteoporosis Center for Treatment and ResearchHong KongChina
  2. 2.Department of Orthopedics and TraumatologyThe Chinese University of Hong KongHong KongChina
  3. 3.Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina
  4. 4.School of Public HealthThe Chinese University of Hong KongHong KongChina
  5. 5.Department of Endocrinology and MetabolismOregon Health Sciences UniversityPortlandUSA
  6. 6.Department of MedicineUniversity of CaliforniaSan FranciscoUSA
  7. 7.Department of EpidemiologyUniversity of PittsburghPittsburghUSA

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