Osteoporosis International

, Volume 16, Issue 12, pp 1803–1808 | Cite as

Short-term effects on bone turnover of replacing milk with cola beverages: a 10-day interventional study in young men

  • Mette Kristensen
  • Marlene Jensen
  • Jane Kudsk
  • Marianne Henriksen
  • Christian Mølgaard
Original Article

Abstract

In the Western world, increased consumption of carbonated soft drinks combined with a decreasing intake of milk may increase the risk of osteoporosis. This study was designed to reflect the trend of replacing milk with carbonated beverages in a group of young men on a low-calcium diet and studies the effects of this replacement on calcium homeostasis and bone turnover. This controlled crossover intervention study included 11 healthy men (22–29 years) who were given a low-calcium basic diet in two 10-day intervention periods with an intervening 10-day washout. During one period, they drank 2.5 l of Coca Cola per day and during the other period 2.5 l of semi-skimmed milk. Serum concentrations of calcium, phosphate, 25-hydroxycholecalciferol, 1,25-dihydroxycholecalciferol (1,25(OH)2D), osteocalcin, bone-specific alkaline phosphatase (B-ALP) and cross-linked C-telopeptides (CTX), plasma intact parathyroid hormone (PTH) and urinary cross-linked N-telopeptides (NTX) were determined at baseline and endpoint of each intervention period. An increase in serum phosphate (P<0.001), 1,25(OH)2D (P<0.001), PTH (P=0.046) and osteocalcin (P<0.001) was observed in the cola period compared to the milk period. Also, bone resorption was significantly increased following the cola period, seen as increased serum CTX (P<0.001) and urinary NTX (P<0.001) compared to the milk period. No changes were observed in serum concentrations of calcium or B-ALP. This study demonstrates that over a 10-day period high intake of cola with a low-calcium diet induces increased bone turnover compared to a high intake of milk with a low-calcium diet. Thus, the trend towards a replacement of milk with cola and other soft drinks, which results in a low calcium intake, may negatively affect bone health as indicated by this short-term study.

Keywords

Bone turnover Calcium intake Cola Milk Osteoporosis Young men 

Notes

Acknowledgement

We would like to thank H. Jensen, H.L. Petersen, K. Ebbesen, B. Hoielt, K.H.B. Larsen and K.G. Rossen for their help with this study. Also, we thank Arla Foods for sponsoring the milk.

References

  1. 1.
    Ettinger MP (2003) Aging bone and osteoporosis: strategies for preventing fractures in the elderly. Arch Intern Med 163:2237–2246PubMedGoogle Scholar
  2. 2.
    World Health Organization (1999) Osteoporosis: Both health organizations and individuals must act now to avoid an impeding epidemic. WHO, GenevaGoogle Scholar
  3. 3.
    Brixen KT, Christensen B, Ejersted C, Langdahl BL (2004) Teriparatide (biosynthetic human parathyroid hormone 1–34): a new paradigm in the treatment of osteoporosis. Pharmacol Toxicol 94:260–270Google Scholar
  4. 4.
    Whiting SJ, Vatanparast H, Baxter-Jones A, Faulkner RA, Mirwald R, Bailey DA (2004) Factors that affect bone mineral accrual in the adolescent growth spurt. J Nutr 134:696S-700PubMedGoogle Scholar
  5. 5.
    Kalkwarf HJ, Khoury JC, Lanphear BP (2003) Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women. Am J Clin Nutr 77:257–265PubMedGoogle Scholar
  6. 6.
    Whiting SJ, Healey A, Psiuk S, Mirwald R, Kowalski K, Bailey DA (2001) Relationship between carbonated and other low nutrient dense beverages and bone mineral content of adolescents. Nutr Res 21:1107–1115Google Scholar
  7. 7.
    Mrdjenovic G, Levitsky DA (2003) Nutritional and energetic consequences of sweetened drink consumption in 6- to 13-year-old children. J Pediatr 142:604–610PubMedGoogle Scholar
  8. 8.
    Harnack L, Stang J, Story M (1999) Soft drink consumption among US children and adolescents: nutritional consequences. J Am Diet Assoc 99:436–441PubMedGoogle Scholar
  9. 9.
    Heaney RP, Rafferty K (2001) Carbonated beverages and urinary calcium excretion. Am J Clin Nutr 74:343–347PubMedGoogle Scholar
  10. 10.
    Wyshak G, Frisch RE (1994) Carbonated beverages, dietary calcium, the dietary calcium/phosphorus ratio, and bone fractures in girls and boys. J Adolesc Health 15:210–215PubMedGoogle Scholar
  11. 11.
    McGartland C, Robson PJ, Murray L et al (2003) Carbonated soft drink consumption and bone mineral density in adolescence: the Northern Ireland Young Hearts project. J Bone Miner Res 18:1563–1569PubMedGoogle Scholar
  12. 12.
    Kim SH, Morton DJ, Barrett-Connor EL (1997) Carbonated beverage consumption and bone mineral density among older women: The Rancho Bernado Study. Am J Public Health 87:276–279PubMedGoogle Scholar
  13. 13.
    Wyshak G (2000) Teenaged girls, carbonated beverage consumption, and bone fractures. Arch Pediatr Adolesc Med 154:610–613PubMedGoogle Scholar
  14. 14.
    Sandström B, Aro A, Becker W, Lyhne N, Pedersen JI, Pórsdóttir I (1996) Nordiska näringsrekommendationer 1996. 113–114 (The Nordic Dietary Recommendations)Google Scholar
  15. 15.
    Johansen DL, Eiken PA (2002) Cola as a possible cause of secondary hyperparathyroidism. Ugeskrift for laeger 164:4290–4291 (report of two case stories)PubMedGoogle Scholar
  16. 16.
    Guerrero-Romero F, Moran MR, Reyes E (1999) Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in postmenopausal women. J Clin Epidemiol 52:1007–1010PubMedGoogle Scholar
  17. 17.
    Mazariegos-Ramos E, Guerrero-Romero F, Rodriguez-Moran M, Lazcano-Burciaga G, Paniagua R, Amato D (1995) Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in children: A case-control study. J Pediatr 126:940–942PubMedGoogle Scholar
  18. 18.
    Petridou E, Karpathios T, Dessypris N, Simou E, Trichopoulos D (1997) The role of dairy products and non alcoholic beverages in bone fractures among school age children. Scand J Soc Med 25:119–125PubMedGoogle Scholar
  19. 19.
    Danish Food and Venterinary Administration (1006) Danskernes Kostvaner 1995. Hovedresultater. Danish Food and Veterinary Administration, Copenhagen, Denmark (survey on the dietary food patterns in the Danish population)Google Scholar
  20. 20.
    Houillier P, Nicolet-Barousse L, Maruani G, Paillard M (2003) What keeps serum calcium levels stable? Joint Bone Spine 70:407–413PubMedGoogle Scholar
  21. 21.
    Calvo MS, Kumar R, Heath H III (1988) Elevated secretion and action of serum parathyroid hormone in young adults consuming high phosphorus, low calcium diets assembled from common foods. J Clin Endocrinol Metab 66:823–829PubMedGoogle Scholar
  22. 22.
    Estepa JC, Aguilera-Tejero E, Lopez I, Almaden Y, Rodriguez M, Felsenfeld AJ (1999) Effect of phosphate on parathyroid hormone secretion in vivo. J Bone Miner Res 14:1848–54.PubMedGoogle Scholar
  23. 23.
    Bizik BK, Ding W, Cerklewski FL (1996) Evidence that bone resorption of young men is not increased by high dietary phosphorus obtained from milk and cheese. Nutr Res 16:1143–1146Google Scholar
  24. 24.
    Metz JA, Anderson JJ, Gallagher PN Jr (1993) Intakes of calcium, phosphorus, and protein, and physical-activity level are related to radial bone mass in young adult women. Am J Clin Nutr 58:537–542PubMedGoogle Scholar
  25. 25.
    Brot C, Jorgensen N, Madsen OR, Jensen LB, Sorensen OH (1999) Relationships between bone mineral density, serum vitamin D metabolites and calcium:phosphorus intake in healthy perimenopausal women. J Int Med 245:509–516Google Scholar
  26. 26.
    United States Institute of Medicine, Food and Nutrition Board (1997) Dietary reference intakes: calcium, phosphorus, magnesium, vitamin D and flouride. National Academy Press, Washington, DCGoogle Scholar
  27. 27.
    Barger-Lux MJ, Heaney RP, Stegman MR (1990) Effects of moderate caffeine intake on the calcium economy of premenopausal women [published erratum appears in Am J Clin Nutr 1991 Jan;53(1):182]. Am J Clin Nutr 52:722–725PubMedGoogle Scholar
  28. 28.
    Kynast-Gales SA, Massey LK (1994) Effect of caffeine on circardian excretion of urinary calcium and magnesium. J Am Coll Nutr 13:467–472PubMedGoogle Scholar
  29. 29.
    Wise KJ, Bergman EA, Sherrard DJ, Massey LK (1996) Interactions between dietary calcium and caffeine consumption on calcium metabolism in hypertensive humans. Am J Hypertens 9:223–229PubMedGoogle Scholar
  30. 30.
    Ginty F (2003) Dietary protein and bone health. Proc.Nutr Soc 62:867–876Google Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • Mette Kristensen
    • 1
  • Marlene Jensen
    • 1
  • Jane Kudsk
    • 1
  • Marianne Henriksen
    • 2
  • Christian Mølgaard
    • 1
  1. 1.Department of Human Nutrition and Center for Advanced Food Studies (LMC)The Royal Veterinary and Agricultural UniversityFrederiksbergDenmark
  2. 2.NycomedRoskildeDenmark

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