Osteoporosis International

, Volume 16, Issue 12, pp 2180–2184

Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system

  • C. E. Fiore
  • S. Riccobene
  • R. Mangiafico
  • F. Santoro
  • P. Pennisi
Case Report


We report a new case of hepatitis C-associated osteosclerosis (HCAO). The clinical presentation of the patient was an acquired deep severe bone pain with increased serum bone alkaline phosphatase activity (up to 12 times the upper limit of normal), and generalized bone sclerosis, temporally related to the hepatitis C-virus (HCV) infection. We documented in this patient an increase of circulating osteoprotegerin (OPG), and a concentration of circulating receptor activator for nuclear factor-kB ligand (RANKL) below the lower limit of the reference range. The observed abnormalities of the OPG/RANKL system may contribute to the maintenance of the positive balance of bone remodeling that characterizes patients with HCAO.


Hepatitis C-associated osteosclerosis OPG RANKL 


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • C. E. Fiore
    • 1
  • S. Riccobene
    • 1
  • R. Mangiafico
    • 1
  • F. Santoro
    • 1
  • P. Pennisi
    • 1
  1. 1.Department of Internal MedicineUniversity of Catania OVECataniaItaly

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