Osteoporosis International

, Volume 16, Issue 9, pp 1042–1048

Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia

  • Masako Ito
  • Akifumi Nishida
  • Kiyoshi Aoyagi
  • Masataka Uetani
  • Kuniaki Hayashi
  • Masahiro Kawase
Original Article

DOI: 10.1007/s00198-004-1802-3

Cite this article as:
Ito, M., Nishida, A., Aoyagi, K. et al. Osteoporos Int (2005) 16: 1042. doi:10.1007/s00198-004-1802-3

Abstract

We determined the effect of risedronate on the trabecular microstructure of ovariectomized rat tibiae, using micro-computed tomography, in order to investigate how changes in microstructure contribute to biomechanical properties. Fifty 18-week-old rats underwent sham operation (n=10) or ovariectomy (OVX) (n=40). The OVX rats were further divided into four groups (n=10 for each group) and treated with risedronate at doses of 0, 0.1, 0.5 or 2.5 mg/kg for 9 months. OVX caused deterioration of three-dimensional trabecular microstructure, notably structure model index (SMI) and connectivity density, while treatment of OVX rats with risedronate at 0.5 and 2.5 mg/kg improved those deleterious microstructural changes. Biomechanical property, as assessed by finite element analysis (FEA), correlated significantly with trabecular bone volume fraction (BV/TV), and the correlation further increased substantially when microstructural parameters were added, especially SMI and connectivity density, with risedronate therapy. Thus, it is suggested that, in addition to increasing bone mass, risedronate improves biomechanical property by maintaining a plate-like structure as well as connectivity of trabeculae.

Keywords

Biomechanical property Connectivity Finite element analysis (FEA) Microstructure Risedronate 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • Masako Ito
    • 1
  • Akifumi Nishida
    • 1
  • Kiyoshi Aoyagi
    • 2
  • Masataka Uetani
    • 1
  • Kuniaki Hayashi
    • 1
  • Masahiro Kawase
    • 3
  1. 1.Department of RadiologyNagasaki University School of MedicineNagasakiJapan
  2. 2.Department of Public HealthNagasaki University School of MedicineNagasakiJapan
  3. 3.Drug Analysis & Pharmacokinetics Research Laboratories, Pharmaceutical Research DivisionTakeda Chemical Industries Ltd.OsakaJapan

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