Osteoporosis International

, Volume 16, Issue 6, pp 581–589 | Cite as

Assessment of fracture risk

  • John A. Kanis
  • Frederik Borgstrom
  • Chris De Laet
  • Helena Johansson
  • Olof Johnell
  • Bengt Jonsson
  • Anders Oden
  • Niklas Zethraeus
  • Bruce Pfleger
  • Nikolai Khaltaev
Review

Abstract

The diagnosis of osteoporosis is based on the measurement of bone mineral density (BMD). There are a number of clinical risk factors that provide information on fracture risk over and above that given by BMD. The assessment of fracture risk thus needs to be distinguished from diagnosis to take account of the independent value of the clinical risk factors. These include age, a prior fragility fracture, a parental history of hip fracture, smoking, use of systemic corticosteroids, excess alcohol intake and rheumatoid arthritis. The independent contribution of these risk factors can be integrated by the calculation of fracture probability with or without the use of BMD. Treatment can then be offered to those identified to have a fracture probability greater than an intervention threshold.

Keywords

Case-finding Clinical risk factors Fracture probability Intervention threshold 

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2004

Authors and Affiliations

  • John A. Kanis
    • 1
  • Frederik Borgstrom
    • 2
  • Chris De Laet
    • 3
  • Helena Johansson
    • 4
  • Olof Johnell
    • 5
  • Bengt Jonsson
  • Anders Oden
    • 4
  • Niklas Zethraeus
    • 6
  • Bruce Pfleger
    • 7
  • Nikolai Khaltaev
    • 8
  1. 1.Centre for Metabolic Bone Diseases (WHO Collaborating Centre)University of Sheffield Medical SchoolSheffieldUK
  2. 2.Stockholm Health EconomicsStockholmSweden
  3. 3.Scientific Institute of Public HealthBrusselsBelgium
  4. 4.RomelandaSweden
  5. 5.Department of OrthopaedicsMalmo General HospitalMalmoSweden
  6. 6.Centre for HealthStockholm School of EconomicsStockholmSweden
  7. 7.AtlantaUSA
  8. 8.GenevaSwitzerland

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