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Osteoporosis International

, Volume 15, Issue 4, pp 290–294 | Cite as

Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal women

  • Anne M. Kenny
  • Karen M. Prestwood
  • Bradley Biskup
  • Bertha Robbins
  • Enid Zayas
  • Alison Kleppinger
  • Joseph A. Burleson
  • Lawrence G. Raisz
Original Article

Abstract

Calcium supplementation is known to increase bone mineral density and decrease fractures, but the relative efficacy of different forms of calcium supplementation is not established. We compared the effects of calcium carbonate and calcium citrate on markers of bone resorption in older postmenopausal women in an open-labeled crossover study. Forty women were randomized to receive 1000 mg/day of either calcium citrate or calcium carbonate for 12 weeks, followed by a 2-week washout without calcium supplements and 12 weeks treatment with the alternate calcium supplement. All women received vitamin D (900 IU/day). Thirty-four women (25 Caucasian, nine Hispanic) completed the study. No significant differences in the decrease in parathyroid hormone (PTH) or bone specific alkaline phosphatase or the increase in urinary calcium/creatinine were detected between the two treatments. However, calcium citrate supplementation decreased the collagen cross-link resorption markers, urinary N-telopeptide (−30%), C-telopeptide (−31%), free deoxypyridinoline (19%) and serum N-telopeptide (−8%), compared to no significant change following calcium carbonate supplementation (+2%, +3%, +2% and +2%, respectively; P<0.05). Calcium citrate decreased markers of bone resorption significantly more than calcium carbonate in postmenopausal women, although no differences in their effects in calcium excretion or PTH were detected.

Keywords

Calcium carbonate Calcium citrate Markers of bone formation Markers of bone resorption 

Notes

Acknowledgements

This work has been supported by the General Clinical Research Center (MO1-RR06192), Claude Pepper OAIC (5P60-AG13631) and Mission Pharmacal. Dr. Kenny has been supported by the Paul Beeson Faculty Scholar Program. In addition, we wish to thank Pamela Fall and Christine Abreu for assistance in the biochemical assays.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2004

Authors and Affiliations

  • Anne M. Kenny
    • 1
  • Karen M. Prestwood
    • 1
  • Bradley Biskup
    • 1
  • Bertha Robbins
    • 3
  • Enid Zayas
    • 1
  • Alison Kleppinger
    • 1
  • Joseph A. Burleson
    • 2
  • Lawrence G. Raisz
    • 3
  1. 1.Center on Aging, MC-5215University of Connecticut Health CenterFarmingtonUSA
  2. 2.Department of Community MedicineUniversity of Connecticut Health CenterFarmingtonUSA
  3. 3.Lowell P. Weicker General Clinical Research CenterUniversity of Connecticut Health CenterFarmingtonUSA

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