Osteoporosis International

, Volume 15, Issue 2, pp 139–144 | Cite as

Characteristics and course of bone mineral densities among fast bone losers in a rural Japanese community: the Miyama Study

  • Noriko Yoshimura
  • Tomoko Takijiri
  • Hirofumi Kinoshita
  • Shigeto Danjoh
  • Takahiro Kasamatsu
  • Seiji Morioka
  • Kiyomi Sakata
  • Tsutomu Hashimoto
  • Tatsuya Takeshita
Original Article

Abstract

The aim of this study was to clarify and compare the temporal course of bone mineral density (BMD) between fast bone losers and normal residents in Miyama Village, a rural Japanese community. BMD was measured over a 10-year period in a cohort study in Miyama Village, Wakayama Prefecture, Japan, to provide information on rate of bone loss in the mature and elderly population. Subjects (n=400) were selected by sex and age stratum from the full list of residents born in 1910–1949, with 50 men and 50 women in each age decade. Baseline BMD of the lumbar spine and proximal femur was measured using dual energy X-ray absorptiometry in 1990, 1993, 1997 and 2000. In the cohort, 171 men and 189 women completed the follow-up survey performed in 1993. After calculating the rate of bone loss between 1990 and 1993, the greatest tertile from the distribution of bone loss was categorized as fast bone losers, with the remainder considered as normal subjects. Changes in BMD were compared between normal subjects and fast bone losers over the 10-year period. Mean rate of change for BMD at both lumbar spine and femoral neck in fast bone losers recovered to levels similar to those in normal subjects over 7 years of observation. By contrast, BMD at the lumbar spine and femoral neck decreased steeply over the 10-year period in both groups, and mean BMD for fast bone losers was significantly lower than that of normal subjects (P<0.05). These differences were apparent only at the lumbar spine in both men and women, even after adjusting for age. These results indicate that fast bone loss is a transient phenomenon rather than a fixed status, although individuals who have been categorized as fast bone losers at some stage continue to display low BMD in the lumbar spine.

Keywords

Body weight Bone mineral density Cohort study Fast bone losers Osteoporosis 

References

  1. 1.
    Hosoda Y, Fujiwara S (1992) The epidemiology of osteoporosis in Japan. J Epidemiol 2:205–213Google Scholar
  2. 2.
    Hashimoto T, Sakata K, Yoshimura N (1997) Epidemiology of osteoporosis in Japan. Osteoporos Int 7:99–102Google Scholar
  3. 3.
    Orimo H, Hashimoto T, Sakata K, Yoshimura N, Suzuki T, Hosoi T (2000) Trends of incidence of hip fracture in Japan, 1987–1997—the third nation-wide survey. J Bone Miner Metabol 18:126–131CrossRefGoogle Scholar
  4. 4.
    Christiansen C, Riis BJ, Rodbro P (1987) Prediction of rapid bone loss in postmenopausal women. Lancet 1:1105–1108CrossRefPubMedGoogle Scholar
  5. 5.
    Yoshimura N (1996) Incidence of fast bone losers and factors affecting changes in bone mineral density: a cohort study in a rural Japanese community. J Bone Miner Metab 14:171–177Google Scholar
  6. 6.
    Kasamatsu T, Yoshimura N, Morioka S, Sugita K, Hashimoto T (1996) A population survey on bone mineral density in a fishing village in Wakayama Prefecture (part I). Distribution of bone mineral density by sex and age on a representative sample of the community. Jpn J Hyg 50:1084–1092 (In Japanese)Google Scholar
  7. 7.
    Yoshimura N, Kasamatsu T, Morioka S, Hashimoto T (1996) A population survey on bone mineral density in a fishing village in Wakayama Prefecture (part 2). The analysis of the risk factors affecting the bone mineral density. Jpn J Hyg 51:677–684 (In Japanese)Google Scholar
  8. 8.
    Yoshimura N, Hashimoto T, Morioka S, Sakata K, Kasamatsu T, Cooper C (1998) Determinants of bone loss in a rural Japanese community: the Taiji Study. Osteoporos Int 8:604–610CrossRefPubMedGoogle Scholar
  9. 9.
    Kasamatsu T, Morioka S, Hashimoto T, Kinoshita H, Yamada H, Tamaki T (1991) Epidemiological study on bone mineral density of inhabitants in Miyama Village, Wakayama Prefecture (part 1). Background of study population and sampling method. J Bone Miner Metab 9:50–55Google Scholar
  10. 10.
    Kinoshita H, Danjoh S, Yamada H et al. (1991) Epidemiological study on the bone mineral density of inhabitants in Miyama Village, Wakayama Prefecture (part II) Bone mineral density of the spine and proximal femur. J Bone Miner Metab 9:56–60Google Scholar
  11. 11.
    Yoshimura N, Kinoshita H, Danjoh S et al. (2002) Bone loss at the lumbar spine and proximal femur in a rural Japanese community, 1990–2000: the Miyama Study. Osteoporos Int 13:803–808CrossRefGoogle Scholar
  12. 12.
    Ministry of Health and Welfare of Japan (1990) Results of National Nutrition Survey 1988. Daiichi-shuppan, TokyoGoogle Scholar
  13. 13.
    Yoshimura N, Kakimoto T, Nishioka M et al. (1997) Evaluation of reproducibility of bone mineral density measured by dual energy X-ray absorptiometry (DPX-L). Wakayama Igaku 48:461 6.14Google Scholar
  14. 14.
    Everitt BS (1995) Cambridge dictionary of statistics in the medical sciences. Cambridge University Press, CambridgeGoogle Scholar
  15. 15.
    Tsunenari T, Yamada S, Kawakatsu M, Negishi H, Tsutsumi M (1995) Menopause-related changes in bone mineral density in Japanese women. A longitudinal study. Calcif Tissue Int 56:5–10PubMedGoogle Scholar
  16. 16.
    Termollieres FA, Poulles JA, Ribot C (1993) Vertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 early postmenopausal women. J Clin Endocrinol Metab 77:683–686PubMedGoogle Scholar
  17. 17.
    Hannan MT, Felson DT, Dawson-Hughes B et al. (2000) Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 15:710–720PubMedGoogle Scholar
  18. 18.
    Dennison E, Eastell R, Fall CHD, Kellingray S, Wood PJ, Cooper C (1999) Determinants of bone loss in elderly men and women: a prospective population-based study. Osteoporos Int 10:384–391CrossRefPubMedGoogle Scholar
  19. 19.
    Foulkes MA, Davis CE (1981) An index of tracking for longitudinal data. Biometrics 37:439–448Google Scholar
  20. 20.
    Burke V, Beikin LJ, Dunbar D (2001) Tracking of blood pressure in Australian children. J Hypertens19:1185–1192Google Scholar
  21. 21.
    Dennison E, Yoshimura N, Hashimoto T, Cooper C (1998) Bone loss in Great Britain and Japan: a comparative longitudinal study. Bone 23:379–382CrossRefPubMedGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2004

Authors and Affiliations

  • Noriko Yoshimura
    • 1
  • Tomoko Takijiri
    • 1
  • Hirofumi Kinoshita
    • 2
  • Shigeto Danjoh
    • 3
  • Takahiro Kasamatsu
    • 4
  • Seiji Morioka
    • 1
  • Kiyomi Sakata
    • 1
  • Tsutomu Hashimoto
    • 5
  • Tatsuya Takeshita
    • 1
  1. 1.Department of Public HealthWakayama Medical University School of Medicine641-0012, WakayamaJapan
  2. 2.Department of OrthopaedicsSaiseikai Wakayama HospitalWakayamaJapan
  3. 3.Department of OrthopaedicsSaiseikai Arita HospitalAritaJapan
  4. 4.Department of Health ScienceKobe City College of NursingKobeJapan
  5. 5.Wakayama Red Cross Blood CenterWakayamaJapan

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