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Osteoporosis International

, Volume 14, Issue 12, pp 995–1000 | Cite as

Vitamin D receptor initiation codon polymorphism, bone density and inflammatory activity of patients with ankylosing spondylitis

  • Barbara M Obermayer-PietschEmail author
  • Uwe Lange
  • Gerlinde Tauber
  • Gerwig Frühauf
  • Astrid Fahrleitner
  • Harald Dobnig
  • Josef Hermann
  • Ferdinand Aglas
  • Joachim Teichmann
  • Gunter Neeck
  • Georg Leb
Original Article

Abstract

Objectives

Osteoporosis is a common finding in ankylosing spondylitis (AS) and may contribute to spinal deformity and bone pain. Bone metabolism as well as inflammatory processes are influenced by the vitamin D receptor gene (VDR). We investigated initiation codon (FokI) and 3’UTR (BsmI) polymorphisms of the VDR for whether there could be an association with bone mineral density (BMD) in relation to bone metabolism or inflammatory activity in patients with AS.

Methods

In this study, 104 patients with AS (m/w 71/33, mean age 41±12 years) were investigated for their lumbar and femoral BMD by DEXA and in part by QCT measurements and compared to 54 healthy controls. Disease activity indices, serum markers of bone metabolism and inflammation were recorded. FokI and BsmI polymorphisms of the VDR were genotyped using genomic DNA from peripheral leukocytes with present or absent restriction sites defined as alleles “f” and “b” or “F” and “B,” respectively.

Results

In male AS patients, FokI genotypes were significantly associated with spinal but not with femoral BMD values (P=0.01) as independent predictors of low BMD, which was also influenced by BMI, and inflammatory and pain indices. CRP and ESR values were also significantly associated with FokI genotypes. BMD in female patients showed no significant association with either FokI or BsmI genotypes of the VDR.

Conclusion

This is the first evidence that the VDR gene may be involved in BMD differences, bone metabolism and inflammatory processes in ankylosing spondylitis. A possible interaction of the vitamin D system, cytokines and bone could define new diagnostic and therapeutic implications in ankylosing spondylitis.

Keywords

Ankylosing spondylitis Bone mineral density Osteoporosis Vitamin D receptor polymorphisms 

Notes

Acknowledgements

We are indebted to Michaela Eichinger, PhD, and Ingrid Halper, Department of Internal Medicine, Karl Franzens University, Graz, Austria, for technical assistance and to Eugenia Lamont for reading the manuscript.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2003

Authors and Affiliations

  • Barbara M Obermayer-Pietsch
    • 1
    Email author
  • Uwe Lange
    • 2
  • Gerlinde Tauber
    • 1
  • Gerwig Frühauf
    • 1
  • Astrid Fahrleitner
    • 1
  • Harald Dobnig
    • 1
  • Josef Hermann
    • 3
  • Ferdinand Aglas
    • 3
  • Joachim Teichmann
    • 2
  • Gunter Neeck
    • 2
  • Georg Leb
    • 1
  1. 1.Department of Internal Medicine, Division of Endocrinology/Nuclear MedicineKarl Franzens UniversityGrazAustria
  2. 2.Kerckhoff Clinic, Department of RheumatologyUniversity of GiessenGiessenGermany
  3. 3.Department of Internal Medicine, Division of RheumatologyKarl Franzens UniversityGrazAustria

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