Osteoporosis International

, Volume 14, Issue 11, pp 895–904 | Cite as

The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos)

  • J. D. Adachi
  • G. Ioannidis
  • L. Pickard
  • C. Berger
  • J. C. Prior
  • L. Joseph
  • D. A. Hanley
  • W. P. Olszynski
  • T. M. Murray
  • T. Anastassiades
  • W. Hopman
  • J. P. Brown
  • S. Kirkland
  • C. Joyce
  • A. Papaioannou
  • S. Poliquin
  • A. Tenenhouse
  • E. A. Papadimitropoulos
Original Article


Osteoporotic fractures can be a major cause of morbidity. It is important to determine the impact of fractures on health-related quality of life (HRQL). A total of 3,394 women and 1,122 men 50 years of age and older, who were recruited for the Canadian Multicentre Osteoporosis Study (CaMos), participated in this cross-sectional study. Minimal trauma fractures of the hip, pelvis, spine, lower body (included upper and lower leg, knee, ankle, and foot), upper body (included arm, elbow, sternum, shoulder, and clavicle), wrist and hand (included forearm, hand, and finger), and ribs were studied. Participants with subclinical vertebral deformities were also examined. The Health Utilities Index Mark II and III Systems were used to assess HRQL. Past osteoporotic fractures varied in prevalence from 1.2% (pelvis) to 27.8% (lower body) in women and 0.3% (pelvis) to 29.3% (wrist) in men. Multivariate linear regression analyses [parameter estimates and corresponding 95% confidence intervals (CI)] indicated that minimal trauma fractures were negatively associated with HRQL and that this relationship depends on fracture type and gender. The multi-attribute scores for the Mark II system were negatively related to hip (−0.05; 95% CI: −0.09, −0.01), lower body (−0.02; 95% CI: −0.03, −0.000), and subclinical vertebral fractures (−0.02; 95% CI: −0.03, −0.00) for women. The multi-attribute scores for the Mark III system were negatively related to hip (−0.09; 95% CI: −0.14, −0.03) and rib fractures (−0.06; 95% CI: −0.11, −0.00) for women, and rib fractures (−0.06; 95% CI: −0.12, −0.00) for men. In conclusion, this study demonstrates a negative association between osteoporotic fractures and quality of life in both women and men.


Fractures Health Utilities Index Osteoporosis Quality of life 



The authors would like to thank the rest of the CaMoS Research Group, including: J Allan, L. Blondeau, B. Gardner-Bray, P. Hartman, J. Thingvold, S. Kirkland, N. Kreiger, P. Krutzen, S. Godmaire, E. Lejeune, B.C. Lentle, B. Matthews, N.Migneault-Roy, M. Parsons, R.S. Rittmaster, L. Robertson, B. Stanfield, and Y. Vigna.

L. Joseph is a senior scientist funded by CIHR. The CaMos was funded by the Senior's Independence Research Program through the National Health Research and Development Program of Health Canada (Project No. 6605-4003-OS). The Medical Research Council of Canada, MRC-PMAC Health Program, Merck Frosst Canada Inc., Eli Lilly Canada Inc., Procter and Gamble Pharmaceuticals Canada Inc., and the Dairy Farmers of Canada.


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2003

Authors and Affiliations

  • J. D. Adachi
    • 1
  • G. Ioannidis
    • 1
  • L. Pickard
    • 1
  • C. Berger
    • 2
  • J. C. Prior
    • 3
  • L. Joseph
    • 4
  • D. A. Hanley
    • 5
  • W. P. Olszynski
    • 6
  • T. M. Murray
    • 7
  • T. Anastassiades
    • 8
  • W. Hopman
    • 8
  • J. P. Brown
    • 9
  • S. Kirkland
    • 10
  • C. Joyce
    • 11
  • A. Papaioannou
    • 1
  • S. Poliquin
    • 12
  • A. Tenenhouse
    • 12
  • E. A. Papadimitropoulos
    • 13
  1. 1.Department of Medicine, St. Joseph's HospitalMcMaster UniversityHamiltonCanada
  2. 2.CaMos Analysis CentreMcGill UniversityMontrealCanada
  3. 3.Department of Medicine/EndocrinologyUniversity of British ColumbiaVancouverCanada
  4. 4.Department of Epidemiology and BiostatisticsMcGill UniversityMontrealCanada
  5. 5.Department of MedicineUniversity of CalgaryCalgaryCanada
  6. 6.Department of MedicineUniversity of SaskatchewanSaskatoonCanada
  7. 7.Department of Medicine, St. Michael's HospitalUniversity of TorontoTorontoCanada
  8. 8.MacKenzie Health Services Research GroupQueen's UniversityKingstonCanada
  9. 9.Department of MedicineLaval UniversitySte-FoyCanada
  10. 10.Department of Community Health and EpidemiologyDalhousie UniversityHalifaxCanada
  11. 11.Department of MedicineMemorial UniversitySt. John'sCanada
  12. 12.CaMos National Coordinating CentreMcGill UniversityMontrealCanada
  13. 13.Eli Lilly and CompanyTorontoCanada

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