Methodological considerations in measurement of bone mineral content
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The strength of bones depends on bone matrix volume, bone microarchitecture, and on the degree of mineralization of bone (DMB), and we have recently shown in patients with osteoporosis treated with alendronate that fracture risk and bone mineralization density (BMD) were changed without modifications of bone matrix volume or bone microarchitecture . Thus, DMB must not be forgotten among the factors determining the mechanical competence of bone.
How to measure qualitative and quantitative differences in the mineral content of bone samples?
Bone mineral content depends on BMD and bone matrix volume. BMD can be quantified by noninvasive methods allowing for a global evaluation of mineral substance of the bone as an organ [dual x-ray absorptiometry (DXA), tomodensitometry, quantitative ultrasound]. Conversely, invasive methods quantify the mineral substance of the bone tissue alone. The 2 methods provide very different information; however, only the latter method will be...
KeywordsBone Mineralization Density Alendronate Raloxifene Teriparatide Strontium Ranelate
The authors express their gratitude to Arthur Santora and John Yates (Merck Research Laboratories, Rahway, NJ) for their constant support. The collaboration of Paul Lips (Amsterdam, The Netherlands), Susan Ott (Seattle, WA), Kristine Harper (Eli Lilly and Company, Indianapolis, IN), Isabelle Tupinon-Mathieu (Institut de Recherches Internationales Servier, Courbevoie, France) is acknowledged. The expert technical assistance of Delphine Farlay, Catherine Simi, and Annie Buffet (INSERM Unité 403, Faculté de Médecine R. Laennec, Lyon, France) is also gratefully acknowledged.
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