Osteoporosis International

, Volume 14, Issue 9, pp 701–715 | Cite as

Searching for osteoporosis genes in the post-genome era: progress and challenges

  • Qing-Yang Huang
  • Robert R. Recker
  • Hong-Wen Deng
Review

Abstract

Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD), deterioration of bone microarchitecture and increased fracture risk. It is a complex disease that has high social and economic costs. Osteoporosis and its associated phenotypes are under the strong genetic control. Identification and characterization of specific loci or genes involved in determining osteoporosis and its associated phenotypes will contribute to a greater understanding of the pathogenesis of osteoporosis, and ultimately might lead to the development of better diagnosis, prevention and treatment strategies. Efforts to identify osteoporosis genes have focused on three approaches: animal models, candidate gene approach, and genome-wide scans. In this article, we review the current status for mapping and identification of genes for osteoporosis, with a focus on some promising regions and future prospects.

Keywords

Bone mineral density Genetics Osteoporosis Osteoporotic fractures 

Notes

Acknowledgements

Investigators of this work are partially supported by grants from Health Future Foundation, NIH grants (K01 AR02170-01, R01 AR45349-01, R01 GM60402-01A1, P01 DC01813-07), grants from State of Nebraska Cancer and Smoking Related Disease Research Program (LB595) and the Nebraska Tobacco Settlement Fund (LB692), US Department of Energy grant DE-FG03–00ER63000/A00, Creighton University, grants (30025025, 30170504, 30230210) from National Science Foundation of China, a Seed Fund (25000106) and a key grant from the Ministry of Education of People's Republic of China, a grant (25000612) from HuNan Normal University, a grant (81017) from Huo Ying Dong Foundation.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2003

Authors and Affiliations

  • Qing-Yang Huang
    • 1
    • 2
    • 3
  • Robert R. Recker
    • 2
  • Hong-Wen Deng
    • 1
    • 2
    • 3
  1. 1.Laboratory of Molecular and Statistical Genetics, College of Life SciencesHunan Normal UniversityChangShaPeople's Republic of China
  2. 2.Osteoporosis Research CenterCreighton UniversityOmahaUSA
  3. 3.Department of Biomedical SciencesCreighton UniversityOmahaUSA

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