Advertisement

Hepatopathien und Drogenkonsum

  • A. BüttnerEmail author
Leitthema
  • 10 Downloads

Zusammenfassung

Hepatopathien bei Drogenmissbrauch umfassen ein breites Spektrum an Veränderungen. Die direkten substanzspezifischen Schädigungen der gängigen missbräuchlich konsumierten Drogen sind i. Allg. als gering einzuschätzen. Problematisch sind allerdings der vielfach gleichzeitige Konsum von Alkohol und Infektionen bei i.v.-Missbrauch mit den bekannten Leberschädigungen. Es wird eine Übersicht der wesentlichen Hepatopathien gegeben.

Schlüsselwörter

Opioide Infektionen Kokain Amphetamine Neue Psychoaktive Substanzen 

Hepatic diseases in the context of drug abuse

Abstract

Hepatic diseases in the context of drug abuse encompass a broad spectrum of alterations. The direct substance-specific damage caused by the commonly consumed illicit drugs in general seems to be low; however, problematic is the concurrent abuse of alcohol or infections in the context of intravenous abuse, which lead to the known hepatic changes. A survey of the main hepatopathies is presented.

Keywords

Opioids Infections Cocaine Amphetamines Novel psychoactive substances 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

A. Büttner gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

Literatur

  1. 1.
    Büttner A, Thieme D, Bidlingmaier M, Madea B (2018) Nebenwirkungen anaboler Substanzen. Rechtsmedizin 28:59–80CrossRefGoogle Scholar
  2. 2.
    Dargan PI, Wood DM (2013) Novel psychoactive substances: classification, pharmacology and toxicology. Academic Press, Elsevier Inc, London, UKGoogle Scholar
  3. 3.
    Darke S, Kaye S, Duflou J (2006) Systemic disease among cases of fatal opioid toxicity. Addiction 101:1299–1305CrossRefGoogle Scholar
  4. 4.
    Delaveris GJ, Hoff-Olsen P, Rogde S (2015) Nonnatural deaths among users of illicit drugs: pathological findings and illicit drug abuse stigmata. Am J Forensic Med Pathol 36:44–48CrossRefGoogle Scholar
  5. 5.
    Edland JF (1972) Liver disease in heroin addicts. Hum Pathol 3:75–84CrossRefGoogle Scholar
  6. 6.
    Ellis AJ, Wendon JA, Portmann B, Williams R (1996) Acute liver damage and ecstasy ingestion. Gut 38:454–458CrossRefGoogle Scholar
  7. 7.
    Falcato L, Graf S, Bruggmann P (2014) Leberschädigungen und Substanzkonsum. Suchtmed Forsch Prax 16:68–79Google Scholar
  8. 8.
    Gerlach D (1980) Post-mortem investigations of fatal cases of narcotic addiction. Forensic Sci Int 15:31–39CrossRefGoogle Scholar
  9. 9.
    Hess C, Maas A, Madea B (2014) „Legal highs“. Chemie, Pharmakologie, Toxikologie und forensische Bedeutung. Rechtsmedizin 24:291–305CrossRefGoogle Scholar
  10. 10.
    Ilić G, Karadžić R, Kostić-Banović L, Antović A (2012) Duration dependent effect of intravenous heroin intake on morphological changes in the liver. Rom J Leg Med 20:13–18CrossRefGoogle Scholar
  11. 11.
    Jones AL, Simpson KJ (1999) Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications. Aliment Pharmacol Ther 13:129–133CrossRefGoogle Scholar
  12. 12.
    Karch SB, Drummer OH (2016) Karch’s pathology of drug abuse, 5. Aufl. CRC Press, Boca Raton, London, New YorkGoogle Scholar
  13. 13.
    Kielland KB, Delaveris GJ, Rogde S, Eide TJ, Amundsen EJ, Dalgard O (2014) Liver fibrosis progression at autopsy in injecting drug users infected by hepatitis C: a longitudinal long-term cohort study. J Hepatol 60:260–266CrossRefGoogle Scholar
  14. 14.
    Kringsholm B, Christoffersen P (1982) Liver pathology in fatal drug addiction. Forensic Sci Int 20:141–151CrossRefGoogle Scholar
  15. 15.
    Kringsholm B, Christoffersen P (1984) Spleen and portal lymph node pathology in fatal drug addiction. Forensic Sci Int 25:233–244CrossRefGoogle Scholar
  16. 16.
    Kringsholm B, Christoffersen P (1987) Lymph-node and thymus pathology in fatal drug addiction. Forensic Sci Int 34:245–254CrossRefGoogle Scholar
  17. 17.
    McCruden EA, Hillan KJ, McKay IC, Cassidy MT, Clark JC (1996) Hepatitis virus infection and liver disease in injecting drug users who died suddenly. J Clin Pathol 49:552–555CrossRefGoogle Scholar
  18. 18.
    Milroy CM, Parai JL (2011) The histopathology of drugs of abuse. Histopathology 59:579–593CrossRefGoogle Scholar
  19. 19.
    Passarino G, Ciccone G, Siragusa R, Tappero P, Mollo F (2005) Histopathological findings in 851 autopsies of drug addicts, with toxicologic and virologic correlations. Am J Forensic Med Pathol 26:106–116Google Scholar
  20. 20.
    Paties C, Peveri V, Falzi G (1987) Liver histopathology in autopsied drug addicts. Forensic Sci Int 35:11–26CrossRefGoogle Scholar
  21. 21.
    Riordan SM, Williams R (1998) Liver disease due to illicit substance use. Addict Biol 3:47–53CrossRefGoogle Scholar
  22. 22.
    Stimmel B, Vernace S, Tobias H (1972) Hepatic dysfunction in heroin addicts. The role of alcohol. JAMA 222:811–812CrossRefGoogle Scholar
  23. 23.
    Tsokos M, Erbersdobler A (2005) Pathology of peliosis. Forensic Sci Int 149:25–33CrossRefGoogle Scholar
  24. 24.
    Trübner K, Polywka S, Püschel K, Laufs R (1991) Hepatitis C in deceased drug addicts. Int J Legal Med 104:251–254CrossRefGoogle Scholar
  25. 25.
    Upreti VV, Eddington ND, Moon K‑H, Song B‑J, Lee IJ (2009) Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine (“ecstasy”). Toxicol Lett 188:167–172CrossRefGoogle Scholar
  26. 26.
    Valente MJ, Carvalho F, Bastos MDL, de Pinho PG, Carvalho M (2012) Contribution of oxidative metabolism to cocaine-induced liver and kidney damage. Curr Med Chem 19:5601–5606CrossRefGoogle Scholar
  27. 27.
    Vitcheva V (2012) Cocaine toxicity and hepatic oxidative stress. Curr Med Chem 19:5677–5682CrossRefGoogle Scholar
  28. 28.
    Wong GL, Tam YH, Ng CF, Chan AW, Choi PC, Chu WC, Lai PB, Chan HL, Wong VW (2014) Liver injury is common among chronic abusers of ketamine. Clin Gastroenterol Hepatol 12:1759–1762CrossRefGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Institut für RechtsmedizinUniversitätsmedizin RostockRostockDeutschland

Personalised recommendations