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Questionnaire-guided evaluation of the effectiveness of long-term intravesical 0.2% chondroitin sulfate therapy in interstitial cystitis

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Introduction and hypothesis

To investigate the long-term feasibility, safety and effectiveness of intravesical chondroitin sulfate therapy in patients with one or more forms of chronic cystitis.


The study included 62 female patients with interstitial cystitis/painful bladder syndrome (IC/PBS) who received intravesical chondroitin sulfate (40 ml/80 mg) therapy between 2014 and 2018. A total of 15 doses of intravesical treatment were applied, once weekly in the first month and once monthly from the second month onward. A 3-day voiding diary, a visual analog scale (VAS), the O'Leary Sant Indexes (ICSI/ICPI), the Pelvic Pain and Urgency/Frequency Symptom (PPUFS) Scale and PPUF Bother scores were recorded and evaluated through prospective comparison before treatment and at the first month and first year. Patients were also assessed using the Global Response Assessment (GRA) at the end of the first month and first year to assess the effectiveness of responses to treatment.


In the first month of treatment, 0.2% chondroitin sulfate was ineffective in 22.5% of patients, with mild improvement observed in 40.0% and moderate-good improvement in 37.0%. Evaluation at the end of the first year revealed mild improvement in 21.0% of patients and moderate-good improvement in 79.0%. Statistically significant improvements were observed in all scoring systems at 1 and 12 months compared with pre-treatment values (p < 0.001).


Long-term intravesical chondroitin sulfate therapy is a safe and highly successful therapeutic modality that produces significant improvement in patients’ quality of life and symptoms in the treatment of IC/PBS.

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Author information

Kocatürk H: Project development, Data collection, Manuscript writing, Literature research. Atasoy N: Data collection, Manuscript editing. Bedir F: Manuscript writing, Data collection, Literature research. Altay MS: Manuscript writing, Manuscript editing. Demirdöğen ŞO: Manuscript editing, Manuscript writing. Erdem K: Manuscript writing, Literature research. Sinan Y: Data analysis, Manuscript writing.

Correspondence to Hüseyin Kocatürk.

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The authors declare they have no conflicts of interest. There was no funding for this study.

Research involving human participants and/or animals

This article does not contain any studies with animals performed by any of the authors.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol (2018/18-171) was approved by the ethics committee of the Health Sciences University Erzurum Regional Education and Research Hospital.

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Informed consent was obtained from all individual participants included in the study.

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Kocatürk, H., Atasoy, N., Bedir, F. et al. Questionnaire-guided evaluation of the effectiveness of long-term intravesical 0.2% chondroitin sulfate therapy in interstitial cystitis. Int Urogynecol J (2020). https://doi.org/10.1007/s00192-020-04245-0

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  • Interstitial cystitis
  • Painful bladder syndrome
  • Intravesical chondroitin sulfate
  • Questionnaires