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The potential role of folate metabolism in interstitial cystitis

  • Carolyn D. Keagy
Review Article
  • 32 Downloads

Abstract

The topic of interstitial cystitis (IC), also known as painful bladder syndrome (PBS), and folate/one carbon metabolism has previously been unaddressed in research. This narrative review highlights a potential connection for those with mast cell-related IC and histamine-mediated pain that is explored through four conceptual sections. The first section focuses on the nature of mast cell involvement and histamine-mediated pain in some interstitial cystitis patients. The second section reviews the literature on folate status in wider allergic conditions. The third section addresses the role of folate and methylation in general in histamine excretion. Finally, folate metabolism and vascular function are addressed because of the vascular abnormalities present in some IC bladders.

Keywords

Interstitial cystitis Painful bladder syndrome Folate Histamine Allergy Vascular endothelial growth factor 

Notes

Compliance with ethical standards

Conflicts of interest

This work is unfunded, and entirely authored by C. Keagy, with no conflicts of interest.

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Copyright information

© The International Urogynecological Association 2018

Authors and Affiliations

  1. 1.Kaiser PermanenteBerkeleyUSA

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