International Urogynecology Journal

, Volume 23, Issue 9, pp 1187–1192 | Cite as

Intravesical hyaluronic acid and chondroitin sulphate for bladder pain syndrome/interstitial cystitis: long-term treatment results

  • M. Cervigni
  • F. Natale
  • L. Nasta
  • A. Mako
Original Article


Introduction and hypothesis

Reconstruction of the glycosaminoglycan layer plays a role in the successful treatment of bladder pain syndrome/interstitial cystitis (BPS/IC). Intravesical instillations of hyaluronic acid (HA) and chondroitin sulphate (CS) have given results in the short term. We hypothesise that these benefits continue in the longer term.


With the aim of evaluating this therapy over a longer period we treated 12 BPS/IC patients refractory to other treatments with a combination of HA 1.6 % and CS 2.0 % over a period of 3 years assessing symptoms and quality of life using a visual analogue scale, 3-day voiding diaries and validated questionnaires.


Improvements in bladder function were sustained for 3 years (mean number of daily voids decreased from 17.8 at baseline to 15.5 at 9 months and 11.9 at 3 years, and mean volume per void from 136.8 ml at baseline to 143.9 ml at 9 months and 180.9 ml at 3 years). Quality of life assessments confirmed these improvements.


Intravesical instillations of HA and CS produced a sustained improvement of the symptomatology, up to 3 years, in patients with BPS/IC refractory to previous treatments. Further confirmation would be expected from larger controlled trials.


Bladder pain syndrome Interstitial cystitis Hyaluronic acid Chondroitin sulphate Intravesical treatment 



Thanks go to David Nicholson for assistance with native English.

Conflicts of interest

M. Cervigni: Consultant for Medtronic and Bard, Speaker for IBSA. F. Natale, L. Nasta and A. Mako: none.


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Copyright information

© The International Urogynecological Association 2012

Authors and Affiliations

  1. 1.Department of UrogynecologySan Carlo HospitalRomeItaly
  2. 2.Italian Interstitial Cystitis AssociationRomeItaly

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