International Urogynecology Journal

, Volume 23, Issue 10, pp 1397–1402

Biomechanical effects of polyglecaprone fibers in a polypropylene mesh after abdominal and rectovaginal implantation in a rabbit

  • Yves Ozog
  • Edoardo Mazza
  • Dirk De Ridder
  • Jan Deprest
Original Article
  • 235 Downloads

Abstract

Introduction and hypothesis

To investigate the biomechanical effects of polyglecaprone fibers in lightweight meshes implanted into the vaginal and abdominal wall of parous rabbits.

Methods

New Zealand White rabbits (n = 24) were implanted with polypropylene meshes (32 g/m2), with (Prolift plus M, n = 12) or without (Prolift minus M, n = 12) polyglecaprone fibers. Following implantation in the posterior vaginal and abdominal wall, local side effects were evaluated and explants underwent uniaxial tensiometry after 120 and 180 days.

Results

The vaginal extrusion rate was at least 50 %, coinciding with a minimum of 20 % of contraction. There were no measurable effects of the addition of polyglecaprone on tensiometric strength and compliance in abdominal explants.

Conclusions

The addition of polyglecaprone fibers did not compromise the biomechanical properties nor did it prevent vaginal extrusion and contraction. The latter as well as some other limitations preclude the rabbit vagina to be a suitable model for biomechanical testing.

Keywords

Contraction Extrusion Polypropylene Polyglecaprone Rabbit 

Copyright information

© The International Urogynecological Association 2012

Authors and Affiliations

  • Yves Ozog
    • 1
  • Edoardo Mazza
    • 2
  • Dirk De Ridder
    • 3
  • Jan Deprest
    • 1
    • 3
    • 4
  1. 1.Center for Surgical Technologies, Faculty of MedicineKatholieke Universiteit LeuvenLeuvenBelgium
  2. 2.Department of Mechanical and Process Engineering, Swiss Federal Institute of TechnologyZurich & EMPA Materials Science and TechnologyDübendorfSwitzerland
  3. 3.Pelvic Floor Unit, Universitair Ziekenhuis “Gasthuisberg” LeuvenKatholieke Universiteit LeuvenLeuvenBelgium
  4. 4.Faculteit GeneeskundeCentre for Surgical TechnologiesLeuvenBelgium

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