Long-term outcome of transurethral injection of hyaluronic acid/dextranomer (NASHA/Dx gel) for the treatment of stress urinary incontinence (SUI)
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Introduction and hypothesis
To investigate the long-term safety and efficacy of transurethral injection of NASHA/Dx gel in women suffering from stress urinary incontinence (SUI).
Women with SUI treated with NASHA/Dx gel via the transurethral Implacer™ device at Mayday University Hospital between November 2002 and December 2003 had long-term outcomes of therapy evaluated.
Eighteen of 21 were followed-up at mean 6.7 years (±SD 0.15). One year after the injection, 11/21 (52.3%) reported improvement. Of the women, 6/21 (28.5%) had a repeat injection and seven (33.3%) women experienced adverse events in the form of periurethral swellings. At 6.7 years, only one of seven women was continent of urine without requiring any further continence procedure, 44.4% were still experiencing SUI symptoms. Nine of 18 (42.8%) had undergone other continence procedures.
Transurethral injection of NASHA/Dx gel in women with SUI is associated with complications and not effective in the long term.
KeywordsNASHA/Dx gel Stress urinary incontinence Urgency Urethral diverticulum Urethral abscess Tension-free vaginal tape
Conflicts of interest
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