International Urogynecology Journal

, Volume 21, Issue 2, pp 157–161 | Cite as

Urodynamic testing and interstitial cystitis/painful bladder syndrome

  • Deeptha N. Sastry
  • Krystal M. Hunter
  • Kristene E. Whitmore
Original Article


Introduction and hypothesis

The objective of this study is to evaluate the relationship between symptom severity in interstitial cystitis/painful bladder syndrome, urodynamic testing (UDT), and cystoscopy.


Charts of subjects who underwent cystoscopy and bladder overdistention (BOD) from January 2006 to July 2007 were reviewed for data points, questionnaires, UDT, and BOD findings. The independent T test and Mann–Whitney U test were performed between questionnaires, urodynamic data, and cystoscopic findings.


Significantly lower volumes on all UDT parameters and higher scores on the interstitial cystitis problem index and pain Likert scale were found in subjects who felt pain with filling on UDT. Significantly lower median volumes for certain urodynamic parameters were found in subjects with high pain Likert scores and O'leary–Sant indices and those with grade 3 glomerulations and anesthetic bladder capacities of less than 600 mL on BOD.


UDT may be a useful adjunctive test in the evaluation of patients with irritative voiding symptoms.


Interstitial cystitis Painful bladder syndrome Urodynamics 



Interstitial cystitis/painful bladder syndrome


Urodynamic testing


Maximum cystometric capacity


Interstitial cystitis problem index


Interstitial cystitis symptom index


Conflicts of interest

Dr. Whitmore: Consultant for Pfizer, Inc, consultant for Astellas Pharmaceutical US, Inc, Research for Boston Scientific


  1. 1.
    Propert KJ, Schaeffer AJ, Brensinger CM, Kusek KW, Nyberg LM, Landis JR (2000) A prospective study of interstitial cystitis: results of longitudinal followup of the Interstitial Cystitis Data Base Cohort. J Urol 163:1434–1439CrossRefPubMedGoogle Scholar
  2. 2.
    Peters KM, Carrico DJ, Diokno AC (2008) Characterization of a clinical cohort of 87 women with Interstitial Cystitis/Painful Bladder Syndrome. Urology 71(4):634–640CrossRefPubMedGoogle Scholar
  3. 3.
    Abrams P, Cardoza L, Fall M, Griffiths D, Rosier P, Ulmsten U et al (2002) The stardardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21:167–178CrossRefPubMedGoogle Scholar
  4. 4.
    Simon LJ, Landis JR, Erickson DR, Nyberg LM (1997) The interstitial cystitis data base study: concepts and preliminary baseline descriptive statistics. Urology 49(5A):64–75CrossRefPubMedGoogle Scholar
  5. 5.
    Driscoll A, Teichman JM (2001) How do patients with interstitial cystitis present? J Urol 166:2118–2120CrossRefPubMedGoogle Scholar
  6. 6.
    Evans RJ, Sant GR (2007) Current diagnosis of interstitial cystitis: an evolving paradigm. Urology 69(Suppl 4A):64–72CrossRefPubMedGoogle Scholar
  7. 7.
    Kirkemo A, Peabody M, Diokno AC, Afanasyev A, Nyberg LM, Landis JR et al (1997) Associations among urodynamic findings and symptoms in women enrolled in the Interstitial Cystitis Data Base (ICDB) study. Urology 49(5A):76–80CrossRefPubMedGoogle Scholar
  8. 8.
    Perez-Marrero R, Emerson L, Juma S (1987) Urodynamic studies in interstitial cystitis. Urology 29(4suppl):27–30PubMedGoogle Scholar
  9. 9.
    Steinkohl WB, Leach GE (1989) Urodynamic findings in interstitial cystitis. Urology 34(6):399–401CrossRefPubMedGoogle Scholar
  10. 10.
    Kuo HC (2003) Urodynamic study and potassium sensitivity test for women with frequency-urgency syndrome and interstitial cystitis. Urol Int 71(1):61–65CrossRefPubMedGoogle Scholar
  11. 11.
    Grégoire M, Liandier F, Naud A, Lacombe L, Fradet Y (2002) Does the potassium stimulation test predict cystometric, cystoscopic outcome in interstitial cystitis? J Urol 168(2):556–557CrossRefPubMedGoogle Scholar
  12. 12.
    O’Leary M, Sant GR, Fowler FJ, Whitmore KE, Spolarich-Kroll J (1997) The interstitial cystitis symptom index and problem index. Urology 49(5A):58–63CrossRefPubMedGoogle Scholar
  13. 13.
    Waxman J, Sulak P, Kuehl T (1998) Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation. J Urol 160(5):1663–1667CrossRefPubMedGoogle Scholar
  14. 14.
    Ingber MS, Peters KM, Killinger KA, Carrico DJ, Ibrahim IA, Diokno AC (2008) Dilemmas in diagnosing pelvic pain: multiple pelvic surgeries common in women with interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct 19:341–345CrossRefPubMedGoogle Scholar
  15. 15.
    Teichman JM, Parsons CL (2007) Contemporary clinical presentation of interstitial cystitis. Urology 69(suppl 4A):41–47CrossRefPubMedGoogle Scholar
  16. 16.
    Messing E, Pauk D, Schaeffer A, Nieweglowski M, Nyberg LM, Landis JR et al (1997) Associations among cystoscopic findings and symptoms and physical examination findings in women enrolled in the Interstitial Cystitis Data Base (ICDB) study. Urology 49(5A suppl):81–85CrossRefPubMedGoogle Scholar
  17. 17.
    Parsons CL, Zupkas P, Parsons JK (2001) Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome. Urology 57:428–432. discussion 432–433CrossRefPubMedGoogle Scholar
  18. 18.
    Lubeck DP, Whitmore KE, Sant GR, Alvarez-Horine S, Lai C (2001) Psychometric validation of the O’Leary–Sant Interstitial Cystitis Symptom Index in a clinical trial of pentosan polysulfate sodium. Urology 57:62–66CrossRefPubMedGoogle Scholar
  19. 19.
    Kushner L, Moldwin R (2006) Efficiency of questionnaires used to screen for interstitial cystitis. J Urol 176:587–592CrossRefPubMedGoogle Scholar
  20. 20.
    Propert KJ, Mayer RD, Sant GR (2006) Responsiveness of symptom scales for interstitial cystitis. Urology 6:55–59CrossRefGoogle Scholar

Copyright information

© The International Urogynecological Association 2009

Authors and Affiliations

  • Deeptha N. Sastry
    • 1
    • 3
  • Krystal M. Hunter
    • 1
  • Kristene E. Whitmore
    • 2
  1. 1.Robert-Wood Johnson Medical School, Cooper University HospitalUniversity of Medicine and Dentistry of New JerseyCamdenUSA
  2. 2.Drexel University College of MedicinePhiladelphiaUSA
  3. 3.Division of Female Pelvic Medicine and Reconstructive Surgery, Robert-Wood Johnson Medical School, Cooper University HospitalUniversity of Medicine and Dentistry of New JerseyCamdenUSA

Personalised recommendations