International Urogynecology Journal

, Volume 18, Issue 7, pp 737–741

Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms

Original Article

Abstract

The objectives of this study are to determine whether patients with overactive bladder (OAB) and nocturia achieved relief of their nighttime voiding symptoms when treated with solifenacin and whether having nocturnal polyuria (NP) affected that response. The patients pooled from four phase III clinical trials were evaluated for reductions in nocturia episodes after treatment with solifenacin (5 or 10 mg) or placebo. A second analysis was performed in patients with and without NP. The patients treated with solifenacin experienced statistically significant reductions in nocturia episodes; median reductions were −35.5% for 5 mg of solifenacin and −36.4% for 10 mg of solifenacin compared with −25.0% for placebo, and significantly more patients treated with solifenacin vs placebo achieved a mean nocturic frequency of ≤1 episode/night. Solifenacin significantly reduced nocturia episodes only in patients without NP (mean change was −0.61 episodes/night for both doses compared with −0.43 episodes for placebo). Solifenacin significantly improved nocturia symptoms only in OAB patients without NP.

Keywords

Nocturnal polyuria Urinary incontinence Muscarinic antagonists Cohort studies Nocturia Lower urinary tract 

Copyright information

© International Urogynecology Journal 2006

Authors and Affiliations

  1. 1.Departments of Obstetrics, Gynecology and Urology, Division of Female Pelvic Medicine and Reconstructive SurgeryLoyola University Medical CenterMaywoodUSA

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