International Urogynecology Journal

, Volume 17, Supplement 1, pp 16–25 | Cite as

The biology behind fascial defects and the use of implants in pelvic organ prolapse repair

  • Jan Deprest
  • Fang Zheng
  • Maja Konstantinovic
  • Federico Spelzini
  • Filip Claerhout
  • Anneke Steensma
  • Yves Ozog
  • Dirk De Ridder
2005 IUGA Grafts Roundtable


Implant materials are increasingly being used in an effort to reduce recurrence after prolapse repair with native tissues. Surgeons should be aware of the biology behind both the disease as well as the host response to various implants. We will discuss insights into the biology behind hernia and abdominal fascial defects. Those lessons from “herniology” will, wherever possible, be applied to pelvic organ prolapse (POP) problems. Then we will deal with available animal models, for both the underlying disease and surgical repair. Then we will go over the features of implants and describe how the host responds to implantation. Methodology of such experiments will be briefly explained for the clinician not involved in experimentation. As we discuss the different materials available on the market, we will summarize some results of recent experiments by our group.


Graft biology Vaginal prolapse Biologic implant Synthetic implant Surgical repair 



Our own animal research has been supported by unconditional grants from Tyco Healthcare, Bard, and Cook. The companies may also have donated standard commercially available implants for experimental implantation. None had input into the surgical protocols, randomization tables, or control on data analysis nor its reporting. The authors have no financial interests in these companies.


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Copyright information

© International Urogynecology Journal 2006

Authors and Affiliations

  • Jan Deprest
    • 1
    • 2
  • Fang Zheng
    • 1
  • Maja Konstantinovic
    • 1
  • Federico Spelzini
    • 1
  • Filip Claerhout
    • 1
  • Anneke Steensma
    • 1
  • Yves Ozog
    • 1
  • Dirk De Ridder
    • 1
  1. 1.Centre for Surgical Technologies, Faculty of Medicine, and Pelvic Floor Centre, Departments of Obstetrics & Gynecology and UrologyUniversity Hospital “Gasthuisberg”, Katholieke Universiteit LeuvenLeuvenBelgium
  2. 2.Centre for Surgical TechnologiesFaculteit Geneeskunde KU LeuvenLeuvenBelgium

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