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Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment?

  • Håkan Alfredson
  • Sture Forsgren
  • Kim Thorsen
  • Martin Fahlström
  • Håkan Johansson
  • Ronny Lorentzon
Sports Medicine

Abstract

In this investigation, we show the presence of both free glutamate (microdialysis) and glutamate NMDAR1 receptors (immunohistochemical analyses of tendon biopsies), in tendons from patients with chronic Achilles tendon pain (Achilles tendinosis) and in controls (pain-free tendons). The NMDAR1 immunoreaction was usually confined to acetylcholinesterase-positive structures, implying that the reaction is present in nerves. Glutamate is a potent pain mediator in the human central nervous system, and in animals it has been shown that peripherally administered glutamate NMDA receptor antagonists diminish the response to formalin-induced nociception. Our present finding of glutamate NMDA receptors in human Achilles tendons might have implications for pain treatment.

Chronic pain Achilles tendon Immunohistochemistry Glutamate NMDA receptors Microdialysis Glutamate 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Håkan Alfredson
    • 1
  • Sture Forsgren
    • 3
  • Kim Thorsen
    • 1
  • Martin Fahlström
    • 1
  • Håkan Johansson
    • 2
  • Ronny Lorentzon
    • 1
  1. 1.Sports Medicine, Department of Surgical and Perioperative Science, University of Umeå, 901 87 UmeåSweden
  2. 2.Centre for Musculoskeletal Research, National Institute for Working Life, University of Umeå, 901 87 UmeåSweden
  3. 3.Department of Integrative Medical Biology, Section for Anatomy, 901 87 UmeåSweden

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