Advertisement

Knee Surgery, Sports Traumatology, Arthroscopy

, Volume 24, Issue 6, pp 1763–1774 | Cite as

The role of meniscal tissue in joint protection in early osteoarthritis

  • Rene Verdonk
  • Henning Madry
  • Nogah Shabshin
  • Florian Dirisamer
  • Giuseppe M. Peretti
  • Nicolas Pujol
  • Tim Spalding
  • Peter Verdonk
  • Romain Seil
  • Vincenzo Condello
  • Berardo Di Matteo
  • Johannes Zellner
  • Peter AngeleEmail author
Knee

Abstract

It is widely accepted that partial meniscectomy leads to early onset of osteoarthritis (OA). A strong correlation exists between the amount and location of the resected meniscus and the development of degenerative changes in the knee. On the other hand, osteoarthritic changes of the joint alter the structural and functional integrity of meniscal tissue. These alterations might additionally compromise the limited healing capacity of the meniscus. In young, active patients without cartilage damage, meniscus therapy including partial meniscectomy, meniscus suture, and meniscus replacement has proven beneficial effects in long-term studies. Even in an early osteoarthritic milieu, there is a relevant regenerative potential of the meniscus and the surrounding cartilage. This potential should be taken into account, and meniscal surgery can be performed with the correct timing and the proper indication even in the presence of early OA.

Level of evidence IV.

Keywords

Meniscus Early OA Partial meniscectomy Meniscal repair Scaffold Allograft 

Notes

Compliance with ethical standards

Conflict of interest

Some of the authors have relationship with Orteq Sports Medicine, London, UK, and Active Implants, Memphis, USA.

References

  1. 1.
    Abdon P, Turner MS, Pettersson H, Lindstrand A, Stenstrom A, Swanson AJ (1990) A long-term follow-up study of total meniscectomy in children. Clin Orthop Relat Res 257:166–170PubMedGoogle Scholar
  2. 2.
    Abraham AC, Pauly HM, Donahue TL (2014) Deleterious effects of osteoarthritis on the structure and function of the meniscal enthesis. Osteoarthr Cartil 22(2):275–283CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Abrams GD, Frank RM, Gupta AK, Harris JD, McCormick FM, Cole BJ (2013) Trends in meniscus repair and meniscectomy in the United States, 2005-2011. Am J Sports Med 41(10):2333–2339CrossRefPubMedGoogle Scholar
  4. 4.
    Accadbled F, Cassard X, Sales de Gauzy J, Cahuzac JP (2007) Meniscal tears in children and adolescents: results of operative treatment. J Pediatr Orthop B 16(1):56–60CrossRefPubMedGoogle Scholar
  5. 5.
    Ahn JH, Kwon OJ, Nam TS (2015) Arthroscopic repair of horizontal meniscal cleavage tears with marrow-stimulating technique. Arthroscopy 31(1):92–98CrossRefPubMedGoogle Scholar
  6. 6.
    Allen CR, Wong EK, Livesay GA, Sakane M, Fu FH, Woo SL (2000) Importance of the medial meniscus in the anterior cruciate ligament-deficient knee. J Orthop Res 18(1):109–115CrossRefPubMedGoogle Scholar
  7. 7.
    Andrish JT (1996) Meniscal injuries in children and adolescents: diagnosis and management. J Am Acad Orthop Surg 4(5):231–237CrossRefPubMedGoogle Scholar
  8. 8.
    Angele P et al (2014) Role of mesenchymal stem cells in meniscal repair. J Exp Orthop 1:12CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Angele P, Muller R, Schumann D, Englert C, Zellner J, Johnstone B, Yoo J, Hammer J, Fierlbeck J, Angele MK, Nerlich M, Kujat R (2009) Characterization of esterified hyaluronan-gelatin polymer composites suitable for chondrogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A 91(2):416–427CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Beaufils P, Hulet C, Dhenain M, Nizard R, Nourissat G, Pujol N (2009) Clinical practice guidelines for the management of meniscal lesions and isolated lesions of the anterior cruciate ligament of the knee in adults. Orthop Traumatol Surg Res 95(6):437–442CrossRefPubMedGoogle Scholar
  11. 11.
    Bhattacharyya T, Gale D, Dewire P, Totterman S, Gale ME, McLaughlin S, Einhorn TA, Felson DT (2003) The clinical importance of meniscal tears demonstrated by magnetic resonance imaging in osteoarthritis of the knee. J Bone Joint Surg Am 85(1):4–9PubMedGoogle Scholar
  12. 12.
    Biedert RM (1993) Intrasubstance meniscal tears. Clinical aspects and the role of MRI. Arch Orthop Trauma Surg 112(3):142–147CrossRefPubMedGoogle Scholar
  13. 13.
    Bloecker K, Guermazi A, Wirth W, Benichou O, Kwoh CK, Hunter DJ, Englund M, Resch H, Eckstein F, Investigators OAI (2013) Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing—data from the Osteoarthritis Initiative. Osteoarthr Cartil 21(3):419–427CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Bloecker K, Wirth W, Guermazi A, Hunter DJ, Resch H, Hochreiter J, Eckstein F (2015) Medial meniscal extrusion relates to cartilage loss in specific femorotibial subregions-data from the osteoarthritis initiative. Arthritis Care Res (Hoboken) 67(11):1545–1552CrossRefGoogle Scholar
  15. 15.
    Bouyarmane H, Beaufils P, Pujol N, Bellemans J, Roberts S, Spalding T, Zaffagnini S, Marcacci M, Verdonk P, Womack M, Verdonk R (2014) Polyurethane scaffold in lateral meniscus segmental defects: clinical outcomes at 24 months follow-up. Orthop Traumatol Surg Res 100(1):153–157CrossRefPubMedGoogle Scholar
  16. 16.
    Bulgheroni P, Murena L, Ratti C, Bulgheroni E, Ronga M, Cherubino P (2010) Follow-up of collagen meniscus implant patients: clinical, radiological, and magnetic resonance imaging results at 5 years. Knee 17(3):224–229CrossRefPubMedGoogle Scholar
  17. 17.
    Busch MT (1990) Meniscal injuries in children and adolescents. Clin Sports Med 9(3):661–680PubMedGoogle Scholar
  18. 18.
    Caplan AI, Dennis JE (2006) Mesenchymal stem cells as trophic mediators. J Cell Biochem 98(5):1076–1084CrossRefPubMedGoogle Scholar
  19. 19.
    Cicuttini FM, Forbes A, Yuanyuan W, Rush G, Stuckey SL (2002) Rate of knee cartilage loss after partial meniscectomy. J Rheumatol 29(9):1954–1956PubMedGoogle Scholar
  20. 20.
    Crues JV 3rd, Mink J, Levy TL, Lotysch M, Stoller DW (1987) Meniscal tears of the knee: accuracy of MR imaging. Radiology 164(2):445–448CrossRefPubMedGoogle Scholar
  21. 21.
    de Girolamo L, Galliera E, Volpi P, Denti M, Dogliotti G, Quaglia A, Cabitza P, Corsi Romanelli MM, Randelli P (2015) Why menisci show higher healing rate when repaired during ACL reconstruction? Growth factors release can be the explanation. Knee Surg Sports Traumatol Arthrosc 23(1):90–96CrossRefPubMedGoogle Scholar
  22. 22.
    De Smet AA, Norris MA, Yandow DR, Quintana FA, Graf BK, Keene JS (1993) MR diagnosis of meniscal tears of the knee: importance of high signal in the meniscus that extends to the surface. Am J Roentgenol 161(1):101–107CrossRefGoogle Scholar
  23. 23.
    De Smet AA, Tuite MJ (2006) Use of the “two-slice-touch” rule for the MRI diagnosis of meniscal tears. Am J Roentgenol 187(4):911–914CrossRefGoogle Scholar
  24. 24.
    Di Matteo B, Perdisa F, Gostynska N, Kon E, Filardo G, Marcacci M (2015) Meniscal scaffolds—preclinical evidence to support their use: a systematic review. Open Orthop J 15(9):143–156CrossRefGoogle Scholar
  25. 25.
    Elsner JJ, Portnoy S, Guilak F, Shterling A, Linder-Ganz E (2010) MRI-based characterization of bone anatomy in the human knee for size matching of a medial meniscal implant. J Biomech Eng 132(10):101008CrossRefPubMedGoogle Scholar
  26. 26.
    Elsner JJ, Portnoy S, Zur G, Guilak F, Shterling A, Linder-Ganz E (2010) Design of a free-floating polycarbonate-urethane meniscal implant using finite element modeling and experimental validation. J Biomech Eng 132(9):095001CrossRefPubMedGoogle Scholar
  27. 27.
    Englund M, Lohmander LS (2004) Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum 50(9):2811–2819CrossRefPubMedGoogle Scholar
  28. 28.
    Englund M, Roos EM, Roos HP, Lohmander LS (2001) Patient-relevant outcomes fourteen years after meniscectomy: influence of type of meniscal tear and size of resection. Rheumatology (Oxford) 40(6):631–639CrossRefGoogle Scholar
  29. 29.
    Fairbank TJ (1948) Knee joint changes after meniscectomy. J Bone Joint Surg Br 30B(4):664–670PubMedGoogle Scholar
  30. 30.
    Filardo G, Andriolo L, Kon E, de Caro F, Marcacci M (2015) Meniscal scaffolds: results and indications A systematic literature review. Int Orthop 39(1):35–46CrossRefPubMedGoogle Scholar
  31. 31.
    Filardo G, Kon E, Roffi A, Di Matteo B, Merli ML, Marcacci M (2015) Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Knee Surg Sports Traumatol Arthrosc 9:2459–2474CrossRefGoogle Scholar
  32. 32.
    Grossman JW, De SmetAA, Shinki K (2009) Comparison of the accuracy rates of 3-T and 1.5-T MRI of the knee in the diagnosis of meniscal tear. Am J Roentgenol 193(2):509–514CrossRefGoogle Scholar
  33. 33.
    Herrlin SV, Wange PO, Lapidus G, Hallander M, Werner S, Weidenhielm L (2013) Is arthroscopic surgery beneficial in treating non-traumatic, degenerative medial meniscal tears? A five year follow-up. Knee Surg Sports Traumatol Arthrosc 21(2):358–364CrossRefPubMedGoogle Scholar
  34. 34.
    Hirschmann MT, Keller L, Hirschmann A, Schenk L, Berbig R, Lüthi U, Amsler F, Friederich NF, Arnold MP (2013) One-year clinical and MR imaging outcome after partial meniscal replacement in stabilized knees using a collagen meniscus implant. Knee Surg Sports Traumatol Arthrosc 21(3):740–747CrossRefPubMedGoogle Scholar
  35. 35.
    Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E (2009) Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect. Stem Cells 27(4):878–887CrossRefPubMedGoogle Scholar
  36. 36.
    Hulet C, Schiltz D, Locker B, Beguin J, Vielpeau C (1998) Lateral meniscal cyst. Retrospective study of 105 cysts treated with arthroscopy with 5 year follow-up. Rev Chir Orthop Reparatrice Appar Mot 84(6):531–538PubMedGoogle Scholar
  37. 37.
    Ishimura M, Tamai S, Fujisawa Y (1991) Arthroscopic meniscal repair with fibrin glue. Arthroscopy 7(2):177–181CrossRefPubMedGoogle Scholar
  38. 38.
    Jung JY, Yoon YC, Kim HR, Choe BK, Wang JH, Jung JY (2013) Knee derangements: comparison of isotropic 3D fast spin-echo, isotropic 3D balanced fast field-echo, and conventional 2D fast spin-echo MR imaging. Radiology 268(3):802–813CrossRefPubMedGoogle Scholar
  39. 39.
    Jung JY, Yoon YC, Kwon JW, Ahn JH, Choe BK (2009) Diagnosis of internal derangement of the knee at 3.0-T MR imaging: 3D isotropic intermediate-weighted versus 2D sequences. Radiology 253(3):780–787CrossRefPubMedGoogle Scholar
  40. 40.
    Katz JN, Brophy RH, Chaisson CE, de Chaves L, Cole BJ, Dahm DL, Donnell-Fink LA, Guermazi A, Haas AK, Jones MH, Levy BA, Mandl LA, Martin SD, Marx RG, Miniaci A, Matava MJ, Palmisano J, Reinke EK, Richardson BE, Rome BN, Safran-Norton CE, Skoniecki DJ, Solomon DH, Smith MV, Spindler KP, Stuart MJ, Wright J, Wright RW, Losina E (2013) Surgery versus physical therapy for a meniscal tear and osteoarthritis. N Engl J Med 368(18):1675–1684CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Khan M, Evaniew N, Bedi A, Ayeni OR, Bhandari M (2014) Arthroscopic surgery for degenerative tears of the meniscus: a systematic review and meta-analysis. CMAJ 186(14):1057–1064CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Kraus T, Heidari N, Svehlik M, Schneider F, Sperl M, Linhart W (2012) Outcome of repaired unstable meniscal tears in children and adolescents. Acta Orthop 83(3):261–266CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    Kurzweil PR, Lynch NM, Coleman S, Kearney B (2014) Repair of horizontal meniscus tears: a systematic review. Arthroscopy 30(11):1513–1519CrossRefPubMedGoogle Scholar
  44. 44.
    Lee SY, Jee WH, Kim JM (2008) Radial tear of the medial meniscal root: reliability and accuracy of MRI for diagnosis. Am J Roentgenol 191(1):81–85CrossRefGoogle Scholar
  45. 45.
    Linder-Ganz E, Elsner JJ, Danino A, Guilak F, Shterling A (2010) A novel quantitative approach for evaluating contact mechanics of meniscal replacements. J Biomech Eng 132(2):024501CrossRefPubMedGoogle Scholar
  46. 46.
    Madry H, Luyten FP, Facchini A (2012) Biological aspects of early osteoarthritis. Knee Surg Sports Traumatol Arthrosc 20(3):407–422CrossRefPubMedGoogle Scholar
  47. 47.
    Madry H, Ziegler R, Orth P, Goebel L, Ong MF, Kohn D, Cucchiarini M, Pape D (2013) Effect of open wedge high tibial osteotomy on the lateral compartment in sheep. Part I: analysis of the lateral meniscus. Knee Surg Sports Traumatol Arthrosc 21(1):39–48CrossRefPubMedGoogle Scholar
  48. 48.
    Manzione M, Pizzutillo PD, Peoples AB, Schweizer PA (1983) Meniscectomy in children: a long-term follow-up study. Am J Sports Med 11(3):111–115CrossRefPubMedGoogle Scholar
  49. 49.
    Matsukura Y, Muneta T, Tsuji K, Koga H, Sekiya I (2014) Mesenchymal stem cells in synovial fluid increase after meniscus injury. Clin Orthop Relat Res 472(5):1357–1364CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    McNicholas MJ, Rowley DI, McGurty D, Adalberth T, Abdon P, Lindstrand A, Lohmander LS (2000) Total meniscectomy in adolescence. A thirty-year follow-up. J Bone Joint Surg Br 82(2):217–221CrossRefPubMedGoogle Scholar
  51. 51.
    Mintzer CM, Richmond JC, Taylor J (1998) Meniscal repair in the young athlete. Am J Sports Med 26(5):630–633PubMedGoogle Scholar
  52. 52.
    Mitchell J, Graham W, Best TM, Collins C, Currie DW, Comstock RD, Flanigan DC (2015) Epidemiology of meniscal injuries in US high school athletes between 2007 and 2013. Knee Surg Sports Traumatol Arthrosc. doi: 10.1007/s00167-015-3814-2 PubMedGoogle Scholar
  53. 53.
    Monllau JC, Gelber PE, Abat F, Pelfort X, Abad R, Hinarejos P, Tey M (2011) Outcome after partial medial meniscus substitution with the collagen meniscal implant at a minimum of 10 years’ follow-up. Arthroscopy 27(7):933–943CrossRefPubMedGoogle Scholar
  54. 54.
    Moran CJ, Withers DP, Kurzweil PR, Verdonk PC (2015) Clinical application of scaffolds for partial meniscus replacement. Sports Med Arthrosc Rev 23(3):156–161CrossRefGoogle Scholar
  55. 55.
    Moseley JB, O’Malley K, Petersen NJ, Menke TJ, Brody BA, Kuykendall DH, Hollingsworth JC, Ashton CM, Wray NP (2002) A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 347(2):81–88CrossRefPubMedGoogle Scholar
  56. 56.
    Noyes FR, Barber-Westin SD (2012) Treatment of meniscus tears during anterior ligament reconstruction. Arthroscopy 28(1):123–130CrossRefPubMedGoogle Scholar
  57. 57.
    Okazaki K, Miura H, Matsuda S, Hashizume M, Iwamoto Y (2006) Arthroscopic resection of the discoid lateral meniscus: long-term follow-up for 16 years. Arthroscopy 22(9):967–971CrossRefPubMedGoogle Scholar
  58. 58.
    Papageorgiou CD, Gil JE, Kanamori A, Fenwick JA, Woo SL, Fu FH (2001) The biomechanical interdependence between the anterior cruciate ligament replacement graft and the medial meniscus. Am J Sports Med 29(2):226–231PubMedGoogle Scholar
  59. 59.
    Paxton ES, Stock MV, Brophy RH (2011) Meniscal repair versus partial meniscectomy: a systematic review comparing reoperation rates and clinical outcomes. Arthroscopy 27(9):1275–1288CrossRefPubMedGoogle Scholar
  60. 60.
    Peretti GM, Gill TJ, Xu JW, Randolph MA, Morse KR, Zaleske DJ (2004) Cell-based therapy for meniscal repair: a large animal study. Am J Sports Med 32(1):146–158CrossRefPubMedGoogle Scholar
  61. 61.
    Pernin J, Verdonk P, Di SelmiTA, Massin P, Neyret P (2010) Long-term follow-up of 24.5 years after intra-articular anterior cruciate ligament reconstruction with lateral extra-articular augmentation. Am J Sports Med 38(6):1094–1102CrossRefPubMedGoogle Scholar
  62. 62.
    Petty CA, Lubowitz JH (2011) Does arthroscopic partial meniscectomy result in knee osteoarthritis? A systematic review with a minimum of 8 years’ follow-up. Arthroscopy 27(3):419–424CrossRefPubMedGoogle Scholar
  63. 63.
    Raber DA, Friederich NF, Hefti F (1998) Discoid lateral meniscus in children. Long-term follow-up after total meniscectomy. J Bone Joint Surg Am 80(11):1579–1586PubMedGoogle Scholar
  64. 64.
    Rodkey WG, DeHaven KE, Montgomery WH 3rd, Baker CL Jr, Beck CL Jr, Hormel SE, Steadman JR, Cole BJ, Briggs KK (2008) Comparison of the collagen meniscus implant with partial meniscectomy. A prospective randomized trial. J Bone Joint Surg Am 90(7):1413–1426CrossRefPubMedGoogle Scholar
  65. 65.
    Roos EM, Ostenberg A, Roos H, Ekdahl C, Lohmander LS (2001) Long-term outcome of meniscectomy: symptoms, function, and performance tests in patients with or without radiographic osteoarthritis compared to matched controls. Osteoarthr Cartil 9(4):316–324CrossRefPubMedGoogle Scholar
  66. 66.
    Roos H, Lauren M, Adalberth T, Roos EM, Jonsson K, Lohmander LS (1998) Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. Arthritis Rheum 41(4):687–693CrossRefPubMedGoogle Scholar
  67. 67.
    Ryu RK, Dunbar VW, Morse GG (2002) Meniscal allograft replacement: a 1-year to 6-year experience. Arthroscopy 18(9):989–994CrossRefPubMedGoogle Scholar
  68. 68.
    Sakaguchi Y, Sekiya I, Yagishita K, Muneta T (2005) Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 52(8):2521–2529CrossRefPubMedGoogle Scholar
  69. 69.
    Samitier G, Alentorn-Geli E, Taylor DC, Rill B, Lock T, Moutzouros V, Kolowich P (2015) Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis. Knee Surg Sports Traumatol Arthrosc 23(1):323–333CrossRefPubMedGoogle Scholar
  70. 70.
    Schminke B, Miosge N (2014) Cartilage repair in vivo: the role of migratory progenitor cells. Curr Rheumatol Rep 16(11):461CrossRefPubMedPubMedCentralGoogle Scholar
  71. 71.
    Scotti C, Hirschmann MT, Antinolfi P, Martin I, Peretti GM (2013) Meniscus repair and regeneration: review on current methods and research potential. Eur Cell Mater 26:150–170PubMedGoogle Scholar
  72. 72.
    Sihvonen R, Paavola M, Malmivaara A, Itala A, Joukainen A, Nurmi H, Kalske J, Jarvinen TL, Finnish Degenerative Meniscal Lesion Study G (2013) Arthroscopic partial meniscectomy versus sham surgery for a degenerative meniscal tear. New Engl J Med 369(26):2515–2524CrossRefPubMedGoogle Scholar
  73. 73.
    Sowers M, Karvonen-Gutierrez CA, Jacobson JA, Jiang Y, Yosef M (2011) Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning. J Bone Joint Surg Am 93(3):241–251CrossRefPubMedPubMedCentralGoogle Scholar
  74. 74.
    Spencer SJ, Saithna A, Carmont MR, Dhillon MS, Thompson P, Spalding T (2012) Meniscal scaffolds: early experience and review of the literature. Knee 19(6):760–765CrossRefPubMedGoogle Scholar
  75. 75.
    Steadman JR, Rodkey WG (2005) Tissue-engineered collagen meniscus implants: 5- to 6-year feasibility study results. Arthroscopy 21(5):515–525CrossRefPubMedGoogle Scholar
  76. 76.
    Stein T, Mehling AP, Welsch F, von Eisenhart-Rothe R, Jager A (2010) Long-term outcome after arthroscopic meniscal repair versus arthroscopic partial meniscectomy for traumatic meniscal tears. Am J Sports Med 38(8):1542–1548CrossRefPubMedGoogle Scholar
  77. 77.
    Stone KR, Walgenbach AW, Turek TJ, Freyer A, Hill MD (2006) Meniscus allograft survival in patients with moderate to severe unicompartmental arthritis: a 2- to 7-year follow-up. Arthroscopy 22(5):469–478CrossRefPubMedGoogle Scholar
  78. 78.
    Takeda Y, Ikata T, Yoshida S, Takai H, Kashiwaguchi S (1998) MRI high-signal intensity in the menisci of asymptomatic children. J Bone Joint Surg Br 80(3):463–467CrossRefPubMedGoogle Scholar
  79. 79.
    Van Dyck P, Vanhoenacker FM, Gielen JL, Dossche L, Weyler J, Parizel PM (2010) Three-Tesla magnetic resonance imaging of the meniscus of the knee: what about equivocal errors? Acta Radiol 51(3):296–301CrossRefPubMedGoogle Scholar
  80. 80.
    Vanderhave KL, Moravek JE, Sekiya JK, Wojtys EM (2011) Meniscus tears in the young athlete: results of arthroscopic repair. J Pediatr Orthop 31(5):496–500CrossRefPubMedGoogle Scholar
  81. 81.
    Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M (2014) Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am 96(2):90–98CrossRefPubMedGoogle Scholar
  82. 82.
    Verbruggen D, Verschueren T, Tampere T, Almqvist K, Victor J, Verdonk R, Verdonk P (2014) Revision of meniscal transplants: long-term clinical follow-up. Knee Surg Sports Traumatol Arthrosc 22(2):351–356CrossRefPubMedGoogle Scholar
  83. 83.
    Verdonk P, Beaufils P, Bellemans J, Djian P, Heinrichs EL, Huysse W, Laprell H, Siebold R, Verdonk R, Actifit Study G (2012) Successful treatment of painful irreparable partial meniscal defects with a polyurethane scaffold: two-year safety and clinical outcomes. Am J Sports Med 40(4):844–853CrossRefPubMedGoogle Scholar
  84. 84.
    Verdonk PC, Demurie A, Almqvist KF, Veys EM, Verbruggen G, Verdonk R (2005) Transplantation of viable meniscal allograft. Survivorship analysis and clinical outcome of one hundred cases. J Bone Joint Surg Am 87(4):715–724CrossRefPubMedGoogle Scholar
  85. 85.
    Verdonk R, Verdonk P, Huysse W, Forsyth R, Heinrichs EL (2011) Tissue ingrowth after implantation of a novel, biodegradable polyurethane scaffold for treatment of partial meniscal lesions. Am J Sports Med 39(4):774–782CrossRefPubMedGoogle Scholar
  86. 86.
    Welsch GH, Juras V, Szomolanyi P, Mamisch TC, Baer P, Kronnerwetter C, Blanke M, Fujita H, Trattnig S (2012) Magnetic resonance imaging of the knee at 3 and 7 tesla: a comparison using dedicated multi-channel coils and optimised 2D and 3D protocols. Eur Radiol 22(9):1852–1859CrossRefPubMedGoogle Scholar
  87. 87.
    Wroble RR, Henderson RC, Campion ER, El-Khoury GY, Albright JP (1992) Meniscectomy in children and adolescents. A long-term follow-up study. Clin Orthop Relat Res 279:180–189PubMedGoogle Scholar
  88. 88.
    Yoon YC, Kim SS, Chung HW, Choe BK, Ahn JH (2007) Diagnostic efficacy in knee MRI comparing conventional technique and multiplanar reconstruction with one-millimeter FSE PDW images. Acta Radiol 48(8):869–874CrossRefPubMedGoogle Scholar
  89. 89.
    Zaffagnini S, Giordano G, Vascellari A, Bruni D, Neri MP, Iacono F, Kon E, Presti ML, Marcacci M (2007) Arthroscopic collagen meniscus implant results at 6 to 8 years follow up. Knee Surg Sports Traumatol Arthrosc 15(2):175–183CrossRefPubMedGoogle Scholar
  90. 90.
    Zaffagnini S, Marcheggiani Muccioli GM, Lopomo N, Bruni D, Giordano G, Ravazzolo G, Molinari M, Marcacci M (2011) Prospective long-term outcomes of the medial collagen meniscus implant versus partial medial meniscectomy: a minimum 10-year follow-up study. Am J Sports Med 39(5):977–985CrossRefPubMedGoogle Scholar
  91. 91.
    Zellner J, Hierl K, Mueller M, Pfeifer C, Berner A, Dienstknecht T, Krutsch W, Geis S, Gehmert S, Kujat R, Dendorfer S, Prantl L, Nerlich M, Angele P (2013) Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone. J Biomed Mater Res B 101(7):1133–1142CrossRefGoogle Scholar
  92. 92.
    Zellner J, Mueller M, Berner A, Dienstknecht T, Kujat R, Nerlich M, Hennemann B, Koller M, Prantl L, Angele M, Angele P (2010) Role of mesenchymal stem cells in tissue engineering of meniscus. J Biomed Mater Res A 94(4):1150–1161PubMedGoogle Scholar
  93. 93.
    Ziegler R, Goebel L, Seidel R, Cucchiarini M, Pape D, Madry H (2015) Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part III: analysis of the microstructure of the subchondral bone and correlations with the articular cartilage and meniscus. Knee Surg Sports Traumatol Arthrosc 23(9):2704–2714CrossRefPubMedGoogle Scholar
  94. 94.
    Zur G, Linder-Ganz E, Elsner JJ, Shani J, Brenner O, Agar G, Hershman EB, Arnoczky SP, Guilak F, Shterling A (2011) Chondroprotective effects of a polycarbonate-urethane meniscal implant: histopathological results in a sheep model. Knee Surg Sports Traumatol Arthrosc 19(2):255–263CrossRefPubMedGoogle Scholar

Copyright information

© European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2016

Authors and Affiliations

  • Rene Verdonk
    • 1
  • Henning Madry
    • 2
  • Nogah Shabshin
    • 3
    • 4
  • Florian Dirisamer
    • 5
  • Giuseppe M. Peretti
    • 6
    • 7
  • Nicolas Pujol
    • 8
  • Tim Spalding
    • 9
  • Peter Verdonk
    • 10
  • Romain Seil
    • 11
  • Vincenzo Condello
    • 12
  • Berardo Di Matteo
    • 13
  • Johannes Zellner
    • 14
  • Peter Angele
    • 14
    • 15
    Email author
  1. 1.Ghent UniversityGhentBelgium
  2. 2.Department of Orthopaedic SurgerySaarland University Medical CenterHomburgGermany
  3. 3.Department of RadiologyCarmel Medical CenterHaifaIsrael
  4. 4.Department of RadiologyHospital of University of PennsylvaniaPhiladelphiaUSA
  5. 5.Orthopädie und SportchirurgieSchloss PuchenauLinz-PuchenauAustria
  6. 6.IRCCS Istituto Ortopedico GaleazziMilanItaly
  7. 7.Department of Biomedical Sciences for HealthUniversity of MilanMilanItaly
  8. 8.Centre hospitalier de VersaillesLe ChesnayFrance
  9. 9.Department of OrthopaedicsUniversity Hospital of Coventry and WarwickshireRugbyUK
  10. 10.Antwerp Orthopedic CenterMonica HospitalsAntwerpBelgium
  11. 11.Clinique d’Eich and Sports Medicine Research Laboratory, Department of Orthopaedic Surgery, Centre Hospitalier LuxembourgLuxembourg Institute of HealthLuxembourgLuxembourg
  12. 12.Dipartimento di Ortopedia - Responsabile di Struttura Semplice di Traumatologia delloSport Knee Surgery and Sports Traumatology Ospedale Sacro Cuore - Don Calabria Via DonNegrar VeronaItaly
  13. 13.II Orthopaedic Clinic and Biomechanics LabIstituto Ortopedico RizzoliBolognaItaly
  14. 14.Department of Trauma SurgeryUniversity Medical Center RegensburgRegensburgGermany
  15. 15.Sporthopaedicum RegensburgRegensburgGermany

Personalised recommendations