Knee Surgery, Sports Traumatology, Arthroscopy

, Volume 20, Issue 9, pp 1815–1821 | Cite as

The value of preoperative grade of radiographic and histological changes in predicting pain relief after total knee arthroplasty for osteoarthritis

  • Henrik LundbladEmail author
  • Andris Kreicbergs
  • Veli Söderlund
  • Ann-Kristin Ulfgren
  • Carl-Olav Stiller
  • Karl-Åke Jansson



Many attempts with contradictory results have been made to correlate different features of OA with pain. One reason may be that pain at rest and pain with movement are seldom considered separately although the mechanisms may be quite different. Furthermore, pain ratings are subject to individual interpretation making an inter-individual comparison questionable. By instead calculating the absolute and relative changes in pain on an intra-individual level after total knee arthroplasty (TKA), we aimed at exploring a relationship between pain and radiological and histological changes.


In 69 patients undergoing TKA, preoperative radiographs and perioperative histological samples of the synovial membrane were graded for severity of osteoarthritic and inflammatory changes. The findings were related to the intensity of pain at rest and with movement both preoperatively and 18 months postoperatively according to the visual analogue scale (VAS).


The radiographic and histological findings showed no significant correlation with the mean pre- or postoperative pain scores. Instead, change in pain with movement from pre- to postoperative was significantly related to the grade of radiographic osteoarthritis. Best pain relief by TKA was achieved in patients with severe radiographic changes. This, however, only applied to pain with movement.


Pain at rest and pain with movement may have different mechanisms. We believe that assessing the intensity of pain at rest and pain with movement separately and considering changes in pain on an individual level will be helpful strategies in future follow-up studies and efforts aimed at explaining the mechanisms of pain in OA.


Pain Osteoarthritis Radiographic Histological Total knee arthroplasty (TKA) 



We thank Gunnar Edman for invaluable help with statistics, also Stockholm Specialistvård AB and Stockholm Spine Center for providing facilities for this study. The Karolinska Institutet and the Folksam research fund financially supported this study.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Henrik Lundblad
    • 1
    Email author
  • Andris Kreicbergs
    • 1
  • Veli Söderlund
    • 2
  • Ann-Kristin Ulfgren
    • 3
    • 4
  • Carl-Olav Stiller
    • 5
  • Karl-Åke Jansson
    • 1
  1. 1.Department of Molecular Medicine and Surgery, Section of OrthopaedicsKarolinska Institutet at Karolinska University Hospital, SolnaStockholmSweden
  2. 2.Department of RadiologyKarolinska Institutet at Karolinska University Hospital, SolnaStockholmSweden
  3. 3.Rheumatology Research Laboratory, CMM L8-004Karolinska Institutet at Karolinska University Hospital, SolnaStockholmSweden
  4. 4.Kibion ABUppsalaSweden
  5. 5.Department of Medicine, Clinical Pharmacology UnitKarolinska Institutet at Karolinska University Hospital, SolnaStockholmSweden

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