Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report

  • A. A. M. DhollanderEmail author
  • F. De Neve
  • K. F. Almqvist
  • R. Verdonk
  • S. Lambrecht
  • D. Elewaut
  • G. Verbruggen
  • P. C. M. Verdonk



This pilot study was designed to describe the technical details and to present the preliminary outcome of autologous matrix-induced chondrogenesis (AMIC) combined with platelet-rich plasma gel, the so called AMIC plus technique, for the treatment of patellar cartilage defects in the knee.


The AMIC plus technique was used for the treatment of (osteo) chondral patellar lesions in the knee. The surgical technique is extensively described. Five patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) and modified MOCART scoring system.


A clinical improvement became apparent after 24 months of follow-up. Both MOCART scoring systems revealed no significant deterioration or improvement of the repair tissue between one and 2 years of follow-up. However, all cases showed subchondral lamina and bone changes. The formation of intralesional osteophytes was observed in 3 of the 5 patients during the 2 years of follow-up.


AMIC plus is feasible for the treatment of symptomatic patellar cartilage defects and resulted in a clinical improvement in all patients. The favourable clinical outcome of the AMIC plus technique was not confirmed by the MRI findings.

Level of evidence



AMIC PRP Knee Cartilage 



The authors would like to thank K. Verstraete and W. Huysse of the Department of Radiology, Ghent University for their support concerning the application of the Magnetic Resonance Imaging facilities.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • A. A. M. Dhollander
    • 1
    • 2
    Email author
  • F. De Neve
    • 1
  • K. F. Almqvist
    • 1
  • R. Verdonk
    • 1
  • S. Lambrecht
    • 2
  • D. Elewaut
    • 2
  • G. Verbruggen
    • 2
  • P. C. M. Verdonk
    • 1
    • 3
  1. 1.Department of Orthopaedic Surgery and TraumatologyGhent University HospitalGhentBelgium
  2. 2.Laboratory of Connective Tissue Biology, Department of RheumatologyGhent University HospitalGhentBelgium
  3. 3.Department of Orthopaedic SurgeryStedelijk Ziekenhuis RoeselareRoeselareBelgium

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