Chondroprotective effects of a polycarbonate-urethane meniscal implant: histopathological results in a sheep model
- 776 Downloads
Injury or loss of the meniscus generally leads to degenerative osteoarthritic changes in the knee joint. However, few surgical options exist for meniscal replacement. The goal of this study was to examine the ability of a non-degradable, anatomically shaped artificial meniscal implant, composed of Kevlar®-reinforced polycarbonate-urethane (PCU), to prevent progressive cartilage degeneration following complete meniscectomy.
The artificial meniscus was implanted in the knees of mature female sheep following total medial meniscectomy, and the animals were killed at 3- and 6-months post-surgery. Macroscopic analysis and semi-quantitative histological analysis were performed on the cartilage of the operated knee and unoperated contralateral control joint.
The PCU implants remained well secured throughout the experimental period and showed no signs of wear or changes in structural or material properties. Histological analysis showed relatively mild cartilage degeneration that was dominated by loss of proteoglycan content and cartilage structure. However, the total osteoarthritis score did not significantly differ between the control and operated knees, and there were no differences in the severity of degenerative changes between 3 and 6 months post-surgery.
Current findings provide preliminary evidence for the ability of an artificial PCU meniscal implant to delay or prevent osteoarthritic changes in knee joint following complete medial meniscectomy.
KeywordsMeniscus Synthetic Meniscectomy Animal model Allograft
We would like to thank Shannon O’Connor, Holly Leddy, and Bridgette Furman for their assistance with the histological analysis and grading.
Conflict of interest statement
This work was supported by Active Implants Corporation.
- 2.Adams M, Hukins D (1992) The extracellular matrix of the meniscus. In: Mow VC, Arnoczky S, Jackson D (eds) Knee meniscus: basic and clinical foundations. Raven Press, New York, NY, pp 15–28Google Scholar
- 6.Brophy RH, Cottrell J, Rodeo SA, Wright TM, Warren RF, Maher SA (2009) Implantation of a synthetic meniscal scaffold improves joint contact mechanics in a partial meniscectomy cadaver model. J Biomed Mater Res A 92:1154–1161Google Scholar
- 12.Cole BJ, Carter TR, Rodeo SA (2002) Allograft meniscal transplantation: background, techniques, and results. J Bone Joint Surg Am 84:1236–1250Google Scholar
- 14.Elliott DM, Jones R 3rd, Setton LA, Scully SP, Vail TP, Guilak F (2002) Joint degeneration following meniscal allograft transplantation in a canine model: mechanical properties and semiquantitative histology of articular cartilage. Knee Surg Sports Traumatol Arthrosc 10:109–118CrossRefPubMedGoogle Scholar
- 22.LeRoux MA, Arokoski J, Vail TP, Guilak F, Hyttinen MM, Kiviranta I, Setton LA (2000) Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy. J Orthop Res 18:383–392CrossRefPubMedGoogle Scholar
- 31.Scholes SC, Burgess IC, Marsden HR, Unsworth A, Jones E, Smith N (2006) Compliant layer acetabular cups: friction testing of a range of materials and designs for a new generation of prosthesis that mimics the natural joint. Proc Inst Mech Eng [H] 220:583–596Google Scholar
- 32.Scholes SC, Unsworth A, Blamey JM, Burgess IC, Jones E, Smith N (2006) Design aspects of compliant, soft layer bearings for an experimental hip prosthesis. Proc Inst Mech Eng [H] 219:79–87Google Scholar
- 34.Smith RA, Hallab NJ (2010) In vitro macrophage response to polyethylene and polycarbonate-urethane particles. J Biomed Mater Res Part A 93:347–355Google Scholar
- 35.Smith RA, Maghsoodpour A, Hallab NJ (2010) In vivo response to cross-linked polyethylene and polycarbonate-urethane particles. J Biomed Mater Res Part A 93:227–234Google Scholar
- 38.Unsworth A, Roberts BJ, Thompson JC (1981) The application of soft layered lubrication to hip prostheses. J Bone Joint Surg 63B:297Google Scholar