Knee Surgery, Sports Traumatology, Arthroscopy

, Volume 18, Issue 12, pp 1645–1655

Autologous chondrocyte implantation for the treatment of cartilage lesions of the knee: a systematic review of randomized studies

  • Haris S. Vasiliadis
  • Jason Wasiak
  • Georgia Salanti

DOI: 10.1007/s00167-010-1050-3

Cite this article as:
Vasiliadis, H.S., Wasiak, J. & Salanti, G. Knee Surg Sports Traumatol Arthrosc (2010) 18: 1645. doi:10.1007/s00167-010-1050-3


Autologous chondrocyte implantation (ACI) techniques are becoming more popular for the treatment of full thickness cartilage lesions of the knee joint. However, there is no systematic information for the efficacy of the new generation ACI techniques compared to other treatment options. A systematic review of the existing evidence from randomized clinical trials of ACI treatment would contribute to understanding the advantages and limitations of this method and would inform the planning of future studies. Using pre-defined criteria, we searched a number of electronic databases to identify all the existing randomized control trials of any type of ACI treatment. Risk of bias was assessed and an analysis of the reported outcomes was performed. Information on the clinical efficacy and safety of ACI compared to other interventions was collected and presented. Nine trials were identified with 626 patients. Patients ranged from 15 to 52 years, and the size of treated lesions was between 1 and 22 cm2. ACI was associated with improvement in clinical outcomes compared to baseline. However, the body of evidence did not suggest any superiority of ACI over other treatments. Complication rates were comparable between interventions except from an increased rate of graft hypertrophies after ACI with periosteum. ACI is an effective treatment for full thickness chondral defects of the knee, providing an improvement of clinical outcomes. However, there is insufficient data to say whether ACI is superior to other treatment strategies. More high quality studies and harmonization in the reported outcomes are needed before specific suggestions for practice can be made.


Cartilage Chondrocyte implantation Knee Repair Chondral Systematic review 

Supplementary material

167_2010_1050_MOESM1_ESM.doc (262 kb)
(DOC 262 kb)

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Haris S. Vasiliadis
    • 1
    • 2
  • Jason Wasiak
    • 3
  • Georgia Salanti
    • 4
  1. 1.Orthopaedic Sports Medicine Center, Department of Orthopaedics, School of MedicineUniversity of IoanninaIoanninaGreece
  2. 2.Molecular Cell Biology and Regenerative Medicine, Sahlgrenska University HospitalGothenburg UniversityGothenburgSweden
  3. 3.Victorian Adult Burns Service and School of Public Health and Preventative Medicine, Alfred HospitalMonash UniversityMelbourneAustralia
  4. 4.Clinical and Molecular Epidemiology Unit, Department of Hygiene and EpidemiologyUniversity of Ioannina School of MedicineIoanninaGreece

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