Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique

  • Antonio PascarellaEmail author
  • Riccardo Ciatti
  • Fabio Pascarella
  • Carmine Latte
  • Mariano Giuseppe Di Salvatore
  • Luciano Liguori
  • Germano Iannella


This study describes a modified AMIC technique consisting of perforations according to Pridie, rather than microfractures, and the covering of the focus of the lesion with a biological collagen patch enriched with bone marrow blood drawn through the knee itself. This technique allows advantages of both the Pridie technique and the in situ proliferation of mesenchymal cells beneath a biological collagen membrane, ‘augmented’, with bone marrow blood. The collagen membrane forms the roof of a ‘biological chamber’, and serves to protect and contains the stem cells as they differentiate into chondrocytes, which will form a healthy regenerative cartilage.


Cartilage Perforations Mesenchymal cell Knee Collagen patch AMIC 



The Authors thank: Roper Amanda Jane, BA Hons, English Literature and History, CELTA, for language editing.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Antonio Pascarella
    • 1
    Email author
  • Riccardo Ciatti
    • 2
  • Fabio Pascarella
    • 1
  • Carmine Latte
    • 1
  • Mariano Giuseppe Di Salvatore
    • 1
  • Luciano Liguori
    • 2
  • Germano Iannella
    • 2
  1. 1.Laboratorio di Chirurgia ArtroscopicaIserniaItaly
  2. 2.Casa di Cura Villa StuartRomeItaly

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