Knee Surgery, Sports Traumatology, Arthroscopy

, Volume 17, Issue 11, pp 1289–1297 | Cite as

Mesenchymal stem cell-based therapy for cartilage repair: a review

  • Hideyuki KogaEmail author
  • Lars Engebretsen
  • Jan E. Brinchmann
  • Takeshi Muneta
  • Ichiro Sekiya


Articular cartilage injury remains one of the major concerns in orthopaedic surgery. Mesenchymal stem cell (MSC) transplantation has been introduced to avoid some of the side effects and complications of current techniques. The purpose of this paper is to review the literature on MSC-based cell therapy for articular cartilage repair to determine if it can be an alternative treatment for cartilage injury. MSCs retain both high proliferative potential and multipotentiality, including chondrogenic differentiation potential, and a number of successful results in transplantation of MSCs into cartilage defects have been reported in animal studies. However, the use of MSCs for cartilage repair is still at the stage of preclinical and phase I studies, and no comparative clinical studies have been reported. Therefore, it is difficult to make conclusions in human studies. This requires randomized clinical trials to evaluate the effectiveness of MSC-based cell therapy for cartilage repair.


Mesenchymal stem cells Cartilage repair Cell transplantation Chondrocytes 



H.K. was supported by a grant from Research Fund of Mitsukoshi Health and Welfare Foundation 2007.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hideyuki Koga
    • 1
    Email author
  • Lars Engebretsen
    • 1
    • 2
    • 3
  • Jan E. Brinchmann
    • 4
  • Takeshi Muneta
    • 5
  • Ichiro Sekiya
    • 6
  1. 1.Oslo Sports Trauma Research CenterNorwegian School of Sports SciencesOsloNorway
  2. 2.Orthopaedic CenterUllevaal University HospitalOsloNorway
  3. 3.Faculty of MedicineUniversity of OsloOsloNorway
  4. 4.Laboratory for Cell Therapy, Institute of ImmunologyRikshospitalet University HospitalOsloNorway
  5. 5.Section of Orthopaedic Surgery, Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan
  6. 6.Section of Cartilage Regeneration, Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan

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