Intensive Care Medicine

, Volume 27, Issue 5, pp 803–811

Pathogenesis and treatment of renal dysfunction in rhabdomyolysis

  • S. Holt
  • K. Moore

DOI: 10.1007/s001340100878

Cite this article as:
Holt, S. & Moore, K. Intensive Care Med (2001) 27: 803. doi:10.1007/s001340100878


Rhabdomyolysis is a major cause of acute renal failure, and recent experimental data have provided a better understanding of the pathophysiology of the renal dysfunction. Renal failure is due to renal vasoconstriction, tubular damage caused by oxidant injury, and possibly tubular obstruction. Recent studies have provided greater insight into the rationale behind current therapy and potential treatment strategies. This review thus aims to summarise current understanding of the causes, pathogenesis and treatment of renal failure caused by rhabdomyolysis.

Rhabdomyolysis Myoglobin Crush syndrome Lipid peroxidation Renal failure 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • S. Holt
    • 1
  • K. Moore
    • 1
  1. 1.Centre for Nephrology and Transplantation, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UKUK

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