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Intensive Care Medicine

, Volume 26, Issue 5, pp 631–634 | Cite as

Ovarian hyperstimulation syndrome (OHSS): diagnosis and management

  • P. Myrianthefs
  • C. Ladakis
  • V. Lappas
  • S. Pactitis
  • A. Carouzou
  • G. Fildisis
  • G. Baltopoulos
BRIEF REPORT

Abstract

Objective: To present our experience and the current knowledge about pathophysiology, diagnosis, and management of the ovarian hyperstimulation syndrome (OHSS). Design: Retrospective study concerning clinical and laboratory findings of severe OHSS. Setting: General ICU at a maternity-surgical hospital. Patients: Ten patients suffering from severe OHSS. Interventions: Supportive and preventive therapeutic measures applied are described. Measurements and results: Admission and discharge data as well as worst values during disease course were recorded. Clinical and laboratory findings showed third space fluid shift leading to weight gain, generalized tissue edema, ascites, hydrothorax, abdominal distension and pain, chest discomfort, hypovolemia, dehydration, ovaries enlargement, electrolyte disturbances, hypoalbuminemia, high hematocrit, urea, and WBC. Conclusions: OHSS is an iatrogenic complication of assisted conception of unknown pathogenesis, with potentially life-threatening sequelae due to hemoconcentration such as circulatory shock, ARDS, hepato-renal failure, thromboembolic phenomena, and multi-organ dysfunction syndrome. Gynecologists and intensivists must be aware of the diagnosis and management of the syndrome because of the widely used reproductive techniques for assisted conception.

Key words Assisted conception Capillary permeability Intensive care Ovarian hyperstimulation syndrome (OHSS) Ovulation induction Third space fluid shift 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • P. Myrianthefs
    • 1
  • C. Ladakis
    • 2
  • V. Lappas
    • 2
  • S. Pactitis
    • 2
  • A. Carouzou
    • 2
  • G. Fildisis
    • 1
  • G. Baltopoulos
    • 1
  1. 1.Athens University School of Nursing ICU, “Agioi Anargyroi” Cancer Hospital of Kifissia, Nea Kifissia 14564, Greece e-mail: pavlosm@mfa.gr Tel.: + 30-1-7 79 16 35,GR
  2. 2.Fax: + 30-1-7 79 16 35

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