Advertisement

Intensive Care Medicine

, Volume 25, Issue 2, pp 207–210 | Cite as

D-dimer assay predicts mortality in critically ill patients without disseminated intravascular coagulation or venous thromboembolic disease

  • A. F. Shorr
  • R. F. Trotta
  • S. A. Alkins
  • G. S. Hanzel
  • L. F. Diehl
ORIGINAL

Abstract

Objective: To determine if D-dimer predicts outcomes in critically ill patients. Design: Observational, cohort study. Setting: Medical intensive care unit (MICU) of a tertiary care hospital. Patients and participants: Seventy-four patients consecutively admitted to the MICU. Interventions: D-dimer was measured by latex agglutination within 12 h of admission to the MICU. Measurements and results: Of the study population, 43.2 % had positive D-dimers. The in-hospital mortality rate in D-dimer positive patients was 28.1 % as compared to 7.1 % in D-dimer negative subjects (p = 0.024). D-dimer positive patients had significantly greater frequencies of venous thromboses (21.9 % vs 4.8 %, p = 0.035). Conclusions: The D-dimer assay identifies patients at increased risk for mortality and may be a more sensitive test to determine the presence of underlying microvascular pathology in critically ill patients. A positive D-dimer at admission to the MICU is associated with an increased risk for the later development of a venous thromboembolic event (VTE).

Key words D-dimer Disseminated intravascular coagulation Mortality 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • A. F. Shorr
    • 1
  • R. F. Trotta
    • 1
  • S. A. Alkins
    • 1
  • G. S. Hanzel
    • 1
  • L. F. Diehl
    • 1
  1. 1.Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, U. S. A., email: Andrew _ F. Shorr @ WRAMAA. CHCS.AMEDD.ARMY.MIL Tel. + 1 2 02-7 82-67 45 Fax + 1 2 02-7 82-90 32

Personalised recommendations