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Intensive Care Medicine

, Volume 24, Issue 7, pp 680–684 | Cite as

Postoperative plasma concentrations of procalcitonin after different types of surgery

  • M. Meisner
  • K. Tschaikowsky
  • A. Hutzler
  • J. Schüttler
  • C. Schick
Original

Abstract

Objective: Procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations were measured after different types of surgery to analyze a possible postoperative induction of procalcitonin (PCT), which might interfere with the diagnosis of bacterial infection or sepsis by PCT.

Design: PCT and CRP plasma levels as well as clinical symptoms of infection were prospectively registered preoperatively and 5 days postoperatively.

Setting: University hospital, in-patient postoperative care.

Patients: Hundred thirty patients were followed up; 117 patients with a normal postoperative course were statistically analyzed.

Interventions: None.

Measurements and results: PCT concentrations were moderately increased above the normal range in 32 % of patients after minor and aseptic surgery, in 59 % after cardiac and thoracic surgery, and in 95 % of patients after surgery of the intestine. In patients with an abnormal postoperative course, PCT was increased in 12 of 13 patients. CRP was increased in almost all patients.

Conclusions: Postoperative induction of PCT largely depends on the type of surgery. Intestinal surgery and major operations more often increase PCT, whereas it is normal in the majority of patients after minor and primarily aseptic surgery. PCT can thus be used postoperatively for diagnostic means only when the range of PCT concentrations during the normal course of a certain type of surgery is considered and concentrations are followed up.

Keywords

Valve Replacement Procalcitonin Thoracic Aortic Aneurysm Plasma Endotoxin Level Diagnostic Means 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dandona P, Nix D, Wilson MF, et al. (1994) Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 79:1605–1608PubMedGoogle Scholar
  2. 2.
    Petitjean S, Mackensen A, Engelhardt R, Bohoun C (1994) Induction de la procalcitonine circulante après administration intraveneuse d’endotoxine chez l’homme. Act Pharm Biol Clin 13: 265–268Google Scholar
  3. 3.
    Al-Nawas B, Krammer I, Shah PM (1996) Procalcitonin in diagnosis of severe infections. Eur J Med Res 1: 331–333PubMedGoogle Scholar
  4. 4.
    Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohoun C (1993) High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341: 515–518PubMedCrossRefGoogle Scholar
  5. 5.
    Brunkhorst FM, Forycki ZF, Wagner J (1995) Frühe Identifizierung der biliären Pankreatitis durch Procalcitonin — Immunreaktivität — vorläufige Ergebnisse. Chir Gastroenterol 11 (Suppl2): 47–50Google Scholar
  6. 6.
    Meisner M, Tschaikowsky K, Beier W, Schüttler J (1996) Procalcitonin (PCT) — ein neuer Parameter zur Diagnose und Verlaufskontrolle von bakteriellen Entzündungen und Sepsis. Anaesthesiol Intensivmed 10 (37): 529–539Google Scholar
  7. 7.
    Meisner M (1996) PCT, Procalcitonin — a new, innovative infection parameter. B.R.A.H.M.S.-Diagnostica, BerlinGoogle Scholar
  8. 8.
    Monneret G, Labaune JM, Isaac C, Bienvenu F, Putet G, Bienvenu J (1997) Procalcitonin and C-reactive protein levels in neonatal infections. Acta Paediatr 86: 209–212PubMedCrossRefGoogle Scholar
  9. 9.
    Marnitz R, Gramm HJ, Zimmermann J (1997) Elaboration of Mediators of inflammatory response after major surgery. Shock 7 (Suppl): 124CrossRefGoogle Scholar
  10. 10.
    Engelmann L, Gundelach K, Pilz U, Werner M (1997) Procalcitonin (PCT) and its relationship to endotoxin (ETX) in sepsis. Intensive Care Med (Suppl 1): 680Google Scholar
  11. 11.
    Berger D, Bolke E, Huegel H, Seidelmann M, Hannekum A, Berger H (1995) New aspects concerning the regulation of the post-operative acute phase reaction during cardiac surgery. Clin Chim Acta 239:121–130PubMedCrossRefGoogle Scholar
  12. 12.
    Carsin H, Assicot M, Feger F, Olivier R, Pennacino I, Le Bever H, Ainaud P, Bohuon C (1997) Evolution and significance of circulating procalcitonin levels compared with IL-6, TNFα and endotoxin levels early after thermal injury. Burns 23: 218–224PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • M. Meisner
    • 1
  • K. Tschaikowsky
    • 2
  • A. Hutzler
    • 2
  • J. Schüttler
    • 2
  • C. Schick
    • 3
  1. 1.Department of AnesthesiologyUniversity of JenaJenaGermany
  2. 2.Department of AnaesthesiologyUniversity of Erlangen-NurembergErlangenGermany
  3. 3.University of Erlangen-NurembergDepartment of SurgeryErlangenGermany

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