Intensive Care Medicine

, Volume 24, Issue 2, pp 97–99 | Cite as

Oxygen supply dependency in critical illness: an evolving understanding

  • P. T. Schumacker


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  1. 1.
    Powers SR, Mannal R, Neclerio M, English M, Marr C, Leather R, Ueda H, Williams G, Custead W, Dutton R (1973) Physiologic consequences of positive end-expiratory pressure. Ann Surg 3: 265–271CrossRefGoogle Scholar
  2. 2.
    Danek SJ, Lynch JP, Weg JG, Dantzer DR (1980) The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syndrome. Am Rev Respir Dis 122: 387–395PubMedGoogle Scholar
  3. 3.
    Mohsenifar Z, Jasper AC, Koerner SK (1988) Relationship between oxygen uptake and oxygen delivery in patients with pulmonary hypertension. Am Rev Respir Dis 138: 69–73PubMedGoogle Scholar
  4. 4.
    Bihari D, Smithies M, Gimson A, Tinker J (1987) The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med 317: 397–402PubMedGoogle Scholar
  5. 5.
    Schumacker PT, Cain SM (1987) The concept of a critical oxygen delivery. Intensive Care Med 13: 223–229PubMedCrossRefGoogle Scholar
  6. 6.
    Dantzker DR, Foresman B, Gutierrez G (1991) Oxygen supply and utilization relationships. A reevaluation. Am Rev Respir Dis 143: 675–679PubMedGoogle Scholar
  7. 7.
    Archie JP Jr (1981) Mathematic coupling of data: a common source of error. Ann Surg 193: 296–303PubMedCrossRefGoogle Scholar
  8. 8.
    Stratton HH, Feustel PJ, Newell JC (1987) Regression of calculated variables in the presence of shared measurement error. J Appl Physiol 62: 2083–2093PubMedGoogle Scholar
  9. 9.
    Annat G, Viale JP, Percival C, Froment M, Motin J (1986) Oxygen delivery and uptake in the adult respiratory distress syndrome. Lack of relationship when measured independently in patients with normal blood lactate concentrations. Am Rev Respir Dis 133: 999–1001PubMedGoogle Scholar
  10. 10.
    Ronco JJ, Fenwick JC, Wiggs BR, Phang PT, Russell JA, Tweeddale MG (1993) Oxygen consumption is independent of increases in oxygen delivery by dobutamine in septic patients who have normal or increased plasma lactate. Am Rev Respir Dis 147: 25–31PubMedGoogle Scholar
  11. 11.
    Ronco JJ, Fenwick JC, Tweeddale MG, Wiggs BR, Phang PT, Cooper CJ, Cunningham KF, Russell JA, Walley KR (1993) Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans. JAMA 270:1724–1730PubMedCrossRefGoogle Scholar
  12. 12.
    Hayes MA, Timmins AC, Yau EHS, Palazzo M, Hinds CJ, Watson D (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330:1717–1722PubMedCrossRefGoogle Scholar
  13. 13.
    Phang PT, Cunningham KF, Ronco JJ, Wiggs BR, Russell JA (1994) Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in ARDS. Am J Respir Crit Care Med 150: 318–323PubMedGoogle Scholar
  14. 14.
    Ronco JJ, Phang PT, Walley KR, Wiggs B, Fenwick JC, Russell JA (1991) Oxygen consumption is independent of changes in oxygen delivery in severe adult respiratory distress syndrome. Am Rev Respir Dis 143:1267–1273PubMedGoogle Scholar
  15. 15.
    Hotchkiss RS, Karl IE (1992) Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 267:1503–1510PubMedCrossRefGoogle Scholar
  16. 16.
    Gutierrez G, Palizas F, Doglio G, Wainsztein N, Gallesio A, Pacin J, Du-bin A, Schiavi E, Jorge M, Pusajo J, Klein F, San Roman E, Dorfman B, Shottlender J, Giniger R (1992) Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 339:195–199PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  1. 1.Pulmonary and Critical Care Medicine MC6026The University of ChicagoChicagoUSA

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