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Intensive Care Medicine

, Volume 23, Issue 10, pp 1089–1092 | Cite as

Inhaled nitric oxide in patients with pulmonary embolism

  • G. Capellier
  • T. Jacques
  • P. Balvay
  • G. Blasco
  • E. Belle
  • F. Barale
BRIEF REPORT

Abstract

Objective: To describe the use of inhaled nitric oxide (NO) in four patients with severe pulmonary embolism. Setting: The intensive care unit (ICU) of a university teaching hospital. Patients: Four patients with severe pulmonary embolism on the basis of clinical, haemodynamic or blood-gas parameters received NO by inhalation either during spontaneous respiration (two cases) or while mechanically ventilated (two cases). Interventions: Conventional management of pulmonary embolism in addition to the use of inhaled NO. Measurements and results: Description of clinical course, haemodynamic and gas-exchange data. Dose-response data are also described for three patients. Conclusions: We reported four cases of pulmonary embolism where the administration of inhaled NO resulted in an improvement in pulmonary haemodynamic and gas-exchange parameters. Two patients were weaned from NO and survived until discharged from the ICU. Inhaled NO might be a useful adjunct in pulmonary embolism to improve stability of the patient prior to thrombolysis or surgery.

Key words Pulmonary embolism Nitric oxide Pulmonary arterial hypertension Cardiac failure Treatment 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • G. Capellier
    • 1
  • T. Jacques
    • 1
  • P. Balvay
    • 1
  • G. Blasco
    • 1
  • E. Belle
    • 1
  • F. Barale
    • 1
  1. 1.Service de Réanimation Médicale, Département d'Anesthésie et de Réanimation, Centre Hospitalier Universitaire Jean Minjoz, Boulevard Fleming, F-25030 Besançon, France, FAX: +33(3)8166 9013FR

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